| Literature DB >> 34896438 |
Aaron A King1, Qianying Lin2, Edward L Ionides3.
Abstract
We construct a family of genealogy-valued Markov processes that are induced by a continuous-time Markov population process. We derive exact expressions for the likelihood of a given genealogy conditional on the history of the underlying population process. These lead to a nonlinear filtering equation which can be used to design efficient Monte Carlo inference algorithms. We demonstrate these calculations with several examples. Existing full-information approaches for phylodynamic inference are special cases of the theory.Entities:
Keywords: Hidden Markov model; Molecular epidemiology; Partially observed Markov process; Phylodynamics; Phylogeny; Statistical inference
Mesh:
Year: 2021 PMID: 34896438 PMCID: PMC8846264 DOI: 10.1016/j.tpb.2021.11.003
Source DB: PubMed Journal: Theor Popul Biol ISSN: 0040-5809 Impact factor: 1.570