Literature DB >> 14726583

Unifying the epidemiological and evolutionary dynamics of pathogens.

Bryan T Grenfell1, Oliver G Pybus, Julia R Gog, James L N Wood, Janet M Daly, Jenny A Mumford, Edward C Holmes.   

Abstract

A key priority for infectious disease research is to clarify how pathogen genetic variation, modulated by host immunity, transmission bottlenecks, and epidemic dynamics, determines the wide variety of pathogen phylogenies observed at scales that range from individual host to population. We call the melding of immunodynamics, epidemiology, and evolutionary biology required to achieve this synthesis pathogen "phylodynamics." We introduce a phylodynamic framework for the dissection of dynamic forces that determine the diversity of epidemiological and phylogenetic patterns observed in RNA viruses of vertebrates. A central pillar of this model is the Evolutionary Infectivity Profile, which captures the relationship between immune selection and pathogen transmission.

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Year:  2004        PMID： 14726583     DOI： 10.1126/science.1090727

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  539 in total

1.  Agent-based and phylogenetic analyses reveal how HIV-1 moves between risk groups: injecting drug users sustain the heterosexual epidemic in Latvia.

Authors:  Frederik Graw; Thomas Leitner; Ruy M Ribeiro
Journal:  Epidemics       Date:  2012-05-02       Impact factor: 4.396

2.  HIV-1 continues to replicate and evolve in patients with natural control of HIV infection.

Authors:  Helene Mens; Mary Kearney; Ann Wiegand; Wei Shao; Kristian Schønning; Jan Gerstoft; Niels Obel; Frank Maldarelli; John W Mellors; Thomas Benfield; John M Coffin
Journal:  J Virol       Date:  2010-10-06       Impact factor: 5.103

3.  Modeling rotavirus strain dynamics in developed countries to understand the potential impact of vaccination on genotype distributions.

Authors:  Virginia E Pitzer; Manish M Patel; Ben A Lopman; Cécile Viboud; Umesh D Parashar; Bryan T Grenfell
Journal:  Proc Natl Acad Sci U S A       Date:  2011-11-14       Impact factor: 11.205

4.  Does history repeat itself? Wavelets and the phylodynamics of influenza A.

Authors:  Jennifer A Tom; Janet S Sinsheimer; Marc A Suchard
Journal:  Mol Biol Evol       Date:  2011-12-08       Impact factor: 16.240

5.  Endogenous or exogenous spreading of HIV-1 in Nordrhein-Westfalen, Germany, investigated by phylodynamic analysis of the RESINA Study cohort.

Authors:  Glenn Lawyer; Eugen Schülter; Rolf Kaiser; Stefan Reuter; Mark Oette; Thomas Lengauer
Journal:  Med Microbiol Immunol       Date:  2012-01-20       Impact factor: 3.402

6.  Making predictive ecology more relevant to policy makers and practitioners.

Authors:  William J Sutherland; Robert P Freckleton
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2012-01-19       Impact factor: 6.237

Review 7.  Molecular phylogenetics: principles and practice.

Authors:  Ziheng Yang; Bruce Rannala
Journal:  Nat Rev Genet       Date:  2012-03-28       Impact factor: 53.242

Review 8.  Contrasting the epidemiological and evolutionary dynamics of influenza spatial transmission.

Authors:  Cécile Viboud; Martha I Nelson; Yi Tan; Edward C Holmes
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2013-02-04       Impact factor: 6.237

9.  Detection, forecasting and control of infectious disease epidemics: modelling outbreaks in humans, animals and plants.

Authors:  Robin N Thompson; Ellen Brooks-Pollock
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2019-06-24       Impact factor: 6.237

10.  Increased frequency of travel in the presence of cross-immunity may act to decrease the chance of a global pandemic.

Authors:  R N Thompson; C P Thompson; O Pelerman; S Gupta; U Obolski
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2019-06-24       Impact factor: 6.237
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