| Literature DB >> 34893494 |
Arielle Elkrief1, Julie T Wu2, Chinmay Jani3, Kyle T Enriquez4, Michael Glover2, Mansi R Shah5, Hira Ghazal Shaikh6, Alicia Beeghly-Fadiel7, Benjamin French7, Sachin R Jhawar8, Douglas B Johnson7, Rana R McKay9, Donna R Rivera10, Daniel Y Reuben11, Surbhi Shah12, Stacey L Tinianov13, Donald Cuong Vinh14, Sanjay Mishra7, Jeremy L Warner15,16.
Abstract
The ongoing coronavirus disease 2019 (COVID-19) pandemic has left patients with current or past history of cancer facing disparate consequences at every stage of the cancer trajectory. This comprehensive review offers a landscape analysis of the current state of the literature on COVID-19 and cancer, including the immune response to COVID-19, risk factors for severe disease, and impact of anticancer therapies. We also review the latest data on treatment of COVID-19 and vaccination safety and efficacy in patients with cancer, as well as the impact of the pandemic on cancer care, including the urgent need for rapid evidence generation and real-world study designs. SIGNIFICANCE: Patients with cancer have faced severe consequences at every stage of the cancer journey due to the COVID-19 pandemic. This comprehensive review offers a landscape analysis of the current state of the field regarding COVID-19 and cancer. We cover the immune response, risk factors for severe disease, and implications for vaccination in patients with cancer, as well as the impact of the COVID-19 pandemic on cancer care delivery. Overall, this review provides an in-depth summary of the key issues facing patients with cancer during this unprecedented health crisis. ©2021 American Association for Cancer Research.Entities:
Mesh：
Year: 2021 PMID： 34893494 PMCID： PMC8831477 DOI： 10.1158/2159-8290.CD-21-1368
Source DB: PubMed Journal: Cancer Discov ISSN： 2159-8274 Impact factor: 38.272