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Literature DB >> 3488964

Monoclonal antibody to a major glycoprotein immunogen mediates differential complement-independent lysis of Trichomonas vaginalis.

Abstract

An immunoglobulin G type 2a (IgG2a) monoclonal antibody (MAb), designated C20A3, which reacts with a highly immunogenic trichomonad membrane glycoprotein (approximately 270,000 daltons), produced complement-independent cytolysis of Trichomonas vaginalis organisms. Time- and temperature-dependent lysis of parasites was observed following incubation of washed, live T. vaginalis with certain concentrations of C20A3 IgG. Differential killing of trichomonal isolates and clones of a given isolate by C20A3 was dependent on the presence of the glycoprotein antigen on the parasite surface.

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Year: 1986 PMID： 3488964 PMCID： PMC260850 DOI： 10.1128/iai.53.3.697-699.1986

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

13 in total

1. Phenotypic variation and diversity among Trichomonas vaginalis isolates and correlation of phenotype with trichomonal virulence determinants.

Authors: J F Alderete; L Kasmala; E Metcalfe; G E Garza
Journal: Infect Immun Date: 1986-08 Impact factor: 3.441

2. Antigenic analysis of Trichomonas vaginalis strains by quantitative fluorescent antibody methods.

Authors: K E Su-Lin; B M Honigberg
Journal: Z Parasitenkd Date: 1983

3. Evaluation of an enzyme-linked immunosorbent assay for the detection of antibody to Trichomonas vaginalis in sera and vaginal secretions.

Authors: D A Street; D Taylor-Robinson; J P Ackers; N F Hanna; A McMillan
Journal: Br J Vener Dis Date: 1982-10

4. Heterogeneity of Trichomonas vaginalis and discrimination among trichomonal isolates and subpopulations with sera of patients and experimentally infected mice.

Authors: J F Alderete; L Suprun-Brown; L Kasmala; J Smith; M Spence
Journal: Infect Immun Date: 1985-09 Impact factor: 3.441

8. Differential susceptibility of fresh Trichomonas vaginalis isolates to complement in menstrual blood and cervical mucus.

Authors: P Demes; A Gombosová; M Valent; A Jánoska; H Fabusová; M Petrenko
Journal: Genitourin Med Date: 1988-06

9. Trichomonas vaginalis with a double-stranded RNA virus has upregulated levels of phenotypically variable immunogen mRNA.

Authors: A Khoshnan; J F Alderete
Journal: J Virol Date: 1994-06 Impact factor: 5.103

10. Analysis of human immunoglobulin-degrading cysteine proteinases of Trichomonas vaginalis.

Authors: D Provenzano; J F Alderete
Journal: Infect Immun Date: 1995-09 Impact factor: 3.441

Monoclonal antibody to a major glycoprotein immunogen mediates differential complement-independent lysis of Trichomonas vaginalis.

1. Phenotypic variation and diversity among Trichomonas vaginalis isolates and correlation of phenotype with trichomonal virulence determinants.

2. Antigenic analysis of Trichomonas vaginalis strains by quantitative fluorescent antibody methods.

3. Evaluation of an enzyme-linked immunosorbent assay for the detection of antibody to Trichomonas vaginalis in sera and vaginal secretions.

4. Heterogeneity of Trichomonas vaginalis and discrimination among trichomonal isolates and subpopulations with sera of patients and experimentally infected mice.

5. Host plasma proteins on the surface of pathogenic Trichomonas vaginalis.

6. Antigen analysis of several pathogenic strains of Trichomonas vaginalis.

7. Soluble Trichomonas vaginalis antigens in cell-free culture supernatants.

8. Monoclonal antibodies to Trypanosoma cruzi inhibit motility and nucleic acid synthesis of culture forms.

9. Identification of immunogenic and antibody-binding membrane proteins of pathogenic Trichomonas vaginalis.

10. Cytotoxicity of monoclonal antibodies to a subset of Giardia isolates.

1. Vaginal antibody of patients with trichomoniasis is to a prominent surface immunogen of Trichomonas vaginalis.

2. In-vitro and in-vivo immunobiological properties of murine monoclonal anti-Brucella antibodies.

3. Antibody enhances killing of Tritrichomonas foetus by the alternative bovine complement pathway.

4. Relatedness of structures of a major immunogen in Trichomonas vaginalis isolates.

Review 5. Clinical and microbiological aspects of Trichomonas vaginalis.

6. Anti-Trichomonas vaginalis monoclonal antibodies inducing complement-dependent cytotoxicity.

7. Analysis of the proteinases of representative Trichomonas vaginalis isolates.

8. Differential susceptibility of fresh Trichomonas vaginalis isolates to complement in menstrual blood and cervical mucus.

9. Trichomonas vaginalis with a double-stranded RNA virus has upregulated levels of phenotypically variable immunogen mRNA.

10. Analysis of human immunoglobulin-degrading cysteine proteinases of Trichomonas vaginalis.