| Literature DB >> 34888112 |
Xiangmin Lv1,2, Chunbo He2,3, Cong Huang1, Guohua Hua1,3, Xingcheng Chen4,5, Barbara K Timm6, Victoria M Maclin6, Abigail A Haggerty7, Shelly K Aust7, Denae M Golden7, Bhavana J Dave7, Yun-An Tseng5, Li Chen1,8, Hongbo Wang1, Peichao Chen1,9, David L Klinkebiel10, Adam R Karpf4, Jixin Dong4, Ronny I Drapkin11, Bo R Rueda1, John S Davis2,4, Cheng Wang1,2.
Abstract
Understanding the cell-of-origin of ovarian high grade serous cancer (HGSC) is the prerequisite for efficient prevention and early diagnosis of this most lethal gynecological cancer. Recently, a mesenchymal type of ovarian HGSC with the poorest prognosis among ovarian cancers was identified by both TCGA and AOCS studies. The cell-of-origin of this subtype of ovarian cancer is unknown. While pursuing studies to understand the role of the Hippo pathway in ovarian granulosa cell physiology and pathology, we unexpectedly found that the Yes-associated protein 1 (YAP1), the major effector of the Hippo signaling pathway, induced dedifferentiation and reprogramming of the ovarian granulosa cells, a unique type of ovarian follicular cells with mesenchymal lineage and high plasticity, leading to the development of high grade ovarian cancer with serous features. Our research results unveil a potential cell-of-origin for a subtype of HGSC with mesenchymal features.Entities:
Keywords: Mesenchymal type of high grade serous cancer; Ovarian granulosa cells; YAP1 oncogene; cell dedifferentiation; cell reprogramming; the Hippo pathway
Year: 2020 PMID： 34888112 PMCID： PMC8654108 DOI： 10.1016/j.scib.2020.03.040
Source DB: PubMed Journal: Sci Bull (Beijing) ISSN： 2095-9273 Impact factor: 20.577