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Literature DB >> 34874450

Oxygen-sensing mechanisms in development and tissue repair.

Yida Jiang¹, Li-Juan Duan¹, Guo-Hua Fong^1,2.

Abstract

Under normoxia, hypoxia inducible factor (HIF) α subunits are hydroxylated by PHDs (prolyl hydroxylase domain proteins) and subsequently undergo polyubiquitylation and degradation. Normal embryogenesis occurs under hypoxia, which suppresses PHD activities and allows HIFα to stabilize and regulate development. In this Primer, we explain molecular mechanisms of the oxygen-sensing pathway, summarize HIF-regulated downstream events, discuss loss-of-function phenotypes primarily in mouse development, and highlight clinical relevance to angiogenesis and tissue repair.

Entities: Chemical

Keywords: Development; Hypoxia inducible factor; Oxygen sensing; Prolyl hydroxylase; Tissue repair

Mesh：

Substances：

Year: 2021 PMID： 34874450 PMCID： PMC8714071 DOI： 10.1242/dev.200030

Source DB: PubMed Journal: Development ISSN： 0950-1991 Impact factor: 6.868

193 in total

1. Supramolecular Polymer Hydrogels for Drug-Induced Tissue Regeneration.

Authors: Jing Cheng; Devang Amin; Jessica Latona; Ellen Heber-Katz; Phillip B Messersmith
Journal: ACS Nano Date: 2019-05-14 Impact factor: 15.881

2. The neuronal oxygen-sensing pathway controls postnatal vascularization of the murine brain.

Authors: Emil Nasyrov; Karen A Nolan; Roland H Wenger; Hugo H Marti; Reiner Kunze
Journal: FASEB J Date: 2019-08-30 Impact factor: 5.191

3. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

Authors: R Ravi; B Mookerjee; Z M Bhujwalla; C H Sutter; D Artemov; Q Zeng; L E Dillehay; A Madan; G L Semenza; A Bedi
Journal: Genes Dev Date: 2000-01-01 Impact factor: 11.361

4. Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver.

Authors: Li-Juan Duan; Kotaro Takeda; Guo-Hua Fong
Journal: Am J Pathol Date: 2014-02-06 Impact factor: 4.307

5. Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning.

Authors: Kakali Sarkar; Zheqing Cai; Rigu Gupta; Nirmal Parajuli; Karen Fox-Talbot; Medha S Darshan; Frank J Gonzalez; Gregg L Semenza
Journal: Proc Natl Acad Sci U S A Date: 2012-06-13 Impact factor: 11.205

6. Randomized Phase I Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Topical Daprodustat in Healthy Volunteers and in Patients With Diabetic Foot Ulcers.

Authors: Eric Olson; Kelly M Mahar; Lisa Morgan; Christina Fillmore; Claire Holland; Lawrence Lavery
Journal: Clin Pharmacol Drug Dev Date: 2019-02-05

Oxygen-sensing mechanisms in development and tissue repair.

1. Supramolecular Polymer Hydrogels for Drug-Induced Tissue Regeneration.

2. The neuronal oxygen-sensing pathway controls postnatal vascularization of the murine brain.

3. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

4. Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver.

5. Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning.

6. Randomized Phase I Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Topical Daprodustat in Healthy Volunteers and in Patients With Diabetic Foot Ulcers.

7. Essential role of developmentally activated hypoxia-inducible factor 1alpha for cardiac morphogenesis and function.

8. The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts.

9. HIF-2α suppresses p53 to enhance the stemness and regenerative potential of human embryonic stem cells.

10. A viral vector expressing hypoxia-inducible factor 1 alpha inhibits hippocampal neuronal apoptosis.

1. Extracellular Vesicles That Herald the Scarcity of Oxygen.