| Literature DB >> 3486962 |
J L Tyler, Y L Yamamoto, M Diksic, J Théron, J G Villemure, C Worthington, A C Evans, W Feindel.
Abstract
The pharmacokinetics of i.v. and superselective intra-arterial carbon-11 1,3-bis-(2-chloroethyl)-1-nitrosourea ([11C]BCNU) were directly compared for the first time in ten patients with recurrent gliomas using positron emission tomography (PET). Intra-arterial administration of [11C]BCNU achieved concentrations of the drug in the tumor that averaged 50 times higher than with a comparable i.v. dose. These preliminary results suggest that the degree of early metabolic trapping of BCNU in tumor correlates with the clinical response to this chemotherapy.Entities:
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Year: 1986 PMID： 3486962
Source DB: PubMed Journal: J Nucl Med ISSN： 0161-5505 Impact factor: 10.057