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Literature DB >> 1902507

Pharmacokinetics of 11C-labelled BCNU and SarCNU in gliomas studied by PET.

S Mitsuki¹, M Diksic, T Conway, Y L Yamamoto, J G Villemure, W Feindel.

Abstract

This paper describes the study of the pharmacodynamics of two 11C-labelled nitrosoureas, 1,3-bis-(2-chloroethyl) nitrosourea (BNCU) and sarcosinamide chloroethylnitrosourea (SarCNU), both labelled in the carbonyl position. Distribution of the radioactivity as measured by positron emission tomography was compared to the distribution of radioactivity observed after injection of 68Ga-EDTA, this being used as an indicator of the blood-brain barrier integrity around the brain tumor. Data suggest that the new nitrosourea, SarCNU, most likely enters brain tissue by different mechanism(s) than BCNU, which enters by diffusion. Data also indicate that use of SarCNU may result in a better tumor to brain ratio than BCNU.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1991 PMID： 1902507 DOI： 10.1007/bf00151246

Source DB: PubMed Journal: J Neurooncol ISSN： 0167-594X Impact factor: 4.130

31 in total

1. Stimulation of protein synthesis and glucose utilization in the hypoglossal nucleus induced by axotomy.

Authors: C B Smith; A M Crane; M Kadekaro; B W Agranoff; L Sokoloff
Journal: J Neurosci Date: 1984-10 Impact factor: 6.167

2. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data.

Authors: C S Patlak; R G Blasberg; J D Fenstermacher
Journal: J Cereb Blood Flow Metab Date: 1983-03 Impact factor: 6.200

3. Pharmacokinetics of 11C-BCNU in experimental brain tumor.

Authors: K Sako; M Diksic; S Farrokhzad; Y L Yamamoto; W Feindel
Journal: J Neurooncol Date: 1985 Impact factor: 4.130

4. Intraarterial 1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy for the treatment of malignant gliomas of the brain: a preliminary report.

Authors: H Safdari; B Mompeon; J B Dubois; C Gros
Journal: Surg Neurol Date: 1985-11

5. Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery.

Authors: M D Walker; S B Green; D P Byar; E Alexander; U Batzdorf; W H Brooks; W E Hunt; C S MacCarty; M S Mahaley; J Mealey; G Owens; J Ransohoff; J T Robertson; W R Shapiro; K R Smith; C B Wilson; T A Strike
Journal: N Engl J Med Date: 1980-12-04 Impact factor: 91.245

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Authors: H S Greenberg; W D Ensminger; W F Chandler; P B Layton; L Junck; J Knake; A K Vine
Journal: J Neurosurg Date: 1984-09 Impact factor: 5.115

7. Comparisons of carmustine, procarbazine, and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma.

Authors: S B Green; D P Byar; M D Walker; D A Pistenmaa; E Alexander; U Batzdorf; W H Brooks; W E Hunt; J Mealey; G L Odom; P Paoletti; J Ransohoff; J T Robertson; R G Selker; W R Shapiro; K R Smith; C B Wilson; T A Strike
Journal: Cancer Treat Rep Date: 1983-02

8. Assessment of [11C]-L-methionine transport into the human brain.

Authors: L A O'Tuama; T R Guilarte; K H Douglass; H N Wagner; D F Wong; R F Dannals; H T Ravert; A A Wilson; N D LaFrance; A N Bice
Journal: J Cereb Blood Flow Metab Date: 1988-06 Impact factor: 6.200

9. Dynamic positron emission tomography for study of cerebral hemodynamics in a cross section of the head using positron-emitting 68Ga-EDTA and 77Kr.

Authors: Y L Yamamoto; C J Thompson; E Meyer; J S Robertson; W Feindel
Journal: J Comput Assist Tomogr Date: 1977-01 Impact factor: 1.826

10. Phase II study--intra-arterial BCNU therapy for metastatic brain tumors.

Authors: S Madajewicz; C R West; H C Park; J Ghoorah; A M Avellanosa; H Takita; C Karakousis; R Vincent; J Caracandas; E Jennings
Journal: Cancer Date: 1981-02-15 Impact factor: 6.860

9 in total

Review 1. Positron emission tomography and the central nervous system.

Authors: R O Robinson; C D Ferrie; M Capra; M N Maisey
Journal: Arch Dis Child Date: 1999-09 Impact factor: 3.791

Review 2. Candidate mechanisms for chemotherapy-induced cognitive changes.

Authors: Tim A Ahles; Andrew J Saykin
Journal: Nat Rev Cancer Date: 2007-03 Impact factor: 60.716

3. Enhanced antitumor activity of sarCNU in comparison to BCNU in an extraneuronal monoamine transporter positive human glioma xenograft model.

Authors: Z P Chen; G Wang; Q Huang; Z F Sun; L Y Zhou; A D Wang; L C Panasci
Journal: J Neurooncol Date: 1999-08 Impact factor: 4.130

4. Relationship between drug delivery and the intra-arterial infusion rate of SarCNU in C6 rat brain tumor model.

Authors: N Takeda; M Diksic
Journal: J Neurooncol Date: 1999-02 Impact factor: 4.130

5. Targeting brain tumors by intra-arterial delivery of cell-penetrating peptides: a novel approach for primary and metastatic brain malignancy.

Authors: Shailendra Joshi; Johann R N Cooke; Jason A Ellis; Charles W Emala; Jeffrey N Bruce
Journal: J Neurooncol Date: 2017-09-05 Impact factor: 4.130