Literature DB >> 3486413

Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor.

K Kaushansky, P J O'Hara, K Berkner, G M Segal, F S Hagen, J W Adamson.   

Abstract

Through the use of long single-sequence oligonucleotide probes, the complete gene for human granulocyte-macrophage colony-stimulating factor (hGM-CSF) has been cloned from a human genomic library. The gene is 2.5 kilobases in length, contains three introns, and is present as a single copy in the human genome. When subcloned into the mammalian expression vector pD3, the gene directs the synthesis of authentic hGM-CSF. In addition to its stimulation of in vitro granulopoiesis and monopoiesis, recombinant hGM-CSF stimulates in vitro erythropoiesis and megakaryopoiesis.

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Year:  1986        PMID： 3486413      PMCID： PMC323460          DOI： 10.1073/pnas.83.10.3101

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  37 in total

1.  Mutagenesis in vitro by DNA polymerase from an RNA tumour virus.

Authors:  K P Gopinathan; L A Weymouth; T A Kunkel; L A Loeb
Journal:  Nature       Date:  1979-04-26       Impact factor: 49.962

2.  A new technique for the assay of infectivity of human adenovirus 5 DNA.

Authors:  F L Graham; A J van der Eb
Journal:  Virology       Date:  1973-04       Impact factor: 3.616

3.  Promoter sequences of eukaryotic protein-coding genes.

Authors:  J Corden; B Wasylyk; A Buchwalder; P Sassone-Corsi; C Kedinger; P Chambon
Journal:  Science       Date:  1980-09-19       Impact factor: 47.728

4.  Direct stimulation by purified GM-CSF of the proliferation of multipotential and erythroid precursor cells.

Authors:  D Metcalf; G R Johnson; A W Burgess
Journal:  Blood       Date:  1980-01       Impact factor: 22.113

5.  The ovalbumin gene-sequence of putative control regions.

Authors:  C Benoist; K O'Hare; R Breathnach; P Chambon
Journal:  Nucleic Acids Res       Date:  1980-01-11       Impact factor: 16.971

Review 6.  The molecular biology and functions of the granulocyte-macrophage colony-stimulating factors.

Authors:  D Metcalf
Journal:  Blood       Date:  1986-02       Impact factor: 22.113

7.  The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA.

Authors:  R M Lawn; E F Fritsch; R C Parker; G Blake; T Maniatis
Journal:  Cell       Date:  1978-12       Impact factor: 41.582

8.  Separation of functionally distinct human granulocyte-macrophage colony-stimulating factors.

Authors:  N A Nicola; D Metcalf; G R Johnson; A W Burgess
Journal:  Blood       Date:  1979-09       Impact factor: 22.113

Review 9.  The nature and action of granulocyte-macrophage colony stimulating factors.

Authors:  A W Burgess; D Metcalf
Journal:  Blood       Date:  1980-12       Impact factor: 22.113

10.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205
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  22 in total

1.  Transcriptional regulation of interleukin 3 gene expression in T lymphocytes.

Authors:  S G Shoemaker; R Hromas; K Kaushansky
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

2.  Binding of SL3-3 enhancer factor 1 transcriptional activators to viral and chromosomal enhancer sequences.

Authors:  A Thornell; B Hallberg; T Grundström
Journal:  J Virol       Date:  1991-01       Impact factor: 5.103

3.  Bovine alpha s1-casein gene sequences direct high level expression of human granulocyte-macrophage colony-stimulating factor in the milk of transgenic mice.

Authors:  M Uusi-Oukari; J M Hyttinen; V P Korhonen; A Västi; L Alhonen; O A Jänne; J Jänne
Journal:  Transgenic Res       Date:  1997-01       Impact factor: 2.788

4.  Interleukin 1 stimulates fibroblasts to synthesize granulocyte-macrophage and granulocyte colony-stimulating factors. Mechanism for the hematopoietic response to inflammation.

Authors:  K Kaushansky; N Lin; J W Adamson
Journal:  J Clin Invest       Date:  1988-01       Impact factor: 14.808

5.  Selective and indirect modulation of human multipotential and erythroid hematopoietic progenitor cell proliferation by recombinant human activin and inhibin.

Authors:  H E Broxmeyer; L Lu; S Cooper; R H Schwall; A J Mason; K Nikolics
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

6.  Recombinant human colony stimulating factor-granulocyte/macrophage and -granulocyte, but not macrophage induce the development of a respiratory burst in primary human myeloid leukemic cells in vitro.

Authors:  K Geissler; G Tricot; G Grimm; P Siostrzonek; H Broxmeyer
Journal:  Blut       Date:  1989-09

7.  Human granulocyte-macrophage colony-stimulating factor is a growth factor active on a variety of cell types of nonhemopoietic origin.

Authors:  S Dedhar; L Gaboury; P Galloway; C Eaves
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

8.  Recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) shortens the period of neutropenia after autologous bone marrow transplantation in a primate model.

Authors:  A W Nienhuis; R E Donahue; S Karlsson; S C Clark; B Agricola; N Antinoff; J E Pierce; P Turner; W F Anderson; D G Nathan
Journal:  J Clin Invest       Date:  1987-08       Impact factor: 14.808

9.  Hemopoietic colony growth-promoting activities in the plasma of bone marrow transplant recipients.

Authors:  K Yamasaki; L A Solberg; N Jamal; G Lockwood; D Tritchler; J E Curtis; M M Minden; K G Mann; H A Messner
Journal:  J Clin Invest       Date:  1988-07       Impact factor: 14.808

10.  Growth of human hemopoietic colonies in response to recombinant gibbon interleukin 3: comparison with human recombinant granulocyte and granulocyte-macrophage colony-stimulating factor.

Authors:  H A Messner; K Yamasaki; N Jamal; M M Minden; Y C Yang; G G Wong; S C Clark
Journal:  Proc Natl Acad Sci U S A       Date:  1987-10       Impact factor: 11.205
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