| Literature DB >> 34861182 |
Abigail E Overacre-Delgoffe1, Hannah J Bumgarner2, Anthony R Cillo3, Ansen H P Burr2, Justin T Tometich4, Amrita Bhattacharjee1, Tullia C Bruno3, Dario A A Vignali3, Timothy W Hand5.
Abstract
The composition of the intestinal microbiota is associated with both the development of tumors and the efficacy of anti-tumor immunity. Here, we examined the impact of microbiota-specific T cells in anti-colorectal cancer (CRC) immunity. Introduction of Helicobacter hepaticus (Hhep) in a mouse model of CRC did not alter the microbial landscape but increased tumor infiltration by cytotoxic lymphocytes and inhibited tumor growth. Anti-tumor immunity was independent of CD8+ T cells but dependent upon CD4+ T cells, B cells, and natural killer (NK) cells. Hhep colonization induced Hhep-specific T follicular helper (Tfh) cells, increased the number of colon Tfh cells, and supported the maturation of Hhep+ tumor-adjacent tertiary lymphoid structures. Tfh cells were necessary for Hhep-mediated tumor control and immune infiltration, and adoptive transfer of Hhep-specific CD4+ T cells to Tfh cell-deficient Bcl6fl/flCd4Cre mice restored anti-tumor immunity. Thus, introduction of immunogenic intestinal bacteria can promote Tfh-associated anti-tumor immunity in the colon, suggesting therapeutic approaches for the treatment of CRC.Entities:
Keywords: T cells; T follicular helper cell; colorectal cancer; microbiome; microbiota-specific T cells; tertiary lymphoid structure; tumor microenvironment
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Year: 2021 PMID： 34861182 PMCID： PMC8865366 DOI： 10.1016/j.immuni.2021.11.003
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745