Wendy Yu1, Denise L Jacobson1, Paige L Williams2, Kunjal Patel3, Mitchell E Geffner4, Russell B Van Dyke5, Deborah Kacanek1, Linda A DiMeglio6, Jennifer Jao7. 1. Center for Biostatistics in AIDS Research. 2. Center for Biostatistics in AIDS Research, Departments of Biostatistics and Epidemiology. 3. Center for Biostatistics in AIDS Research, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts. 4. The Saban Research Institute of Children's Hospital Los Angeles, Keck School of Medicine of USC, Los Angeles, California. 5. Tulane University School of Medicine, Department of Pediatrics, New Orleans, Los Angeles. 6. Indiana University School of Medicine, Department of Pediatrics, Indianapolis, Indiana. 7. Northwestern University Feinberg School of Medicine, Department of Pediatrics, Department of Medicine, Chicago, Illinois, USA.
Abstract
OBJECTIVE: The aim of this study was to compare long-term growth between HIV-exposed uninfected children (CHEU) born to women with perinatally acquired HIV (CHEU-PHIV) and CHEU born to women with nonperinatally acquired HIV (CHEU-NPHIV). DESIGN: A longitudinal analysis of anthropometric measurements from a U.S.-based multisite prospective cohort study enrolling CHEU and their mothers since April 2007. METHODS: CHEU were evaluated for growth annually from birth through age 5 and again at age 7 years. Z-scores were calculated using U.S. growth references for weight (WTZ), height (HTZ), and weight-for-length or BMI-for-age (WLZ/BMIZ). Mid-upper arm circumference (MUACZ) and triceps skinfold thickness (TSFZ) Z-scores were obtained from ages 1 and 2, respectively, through age 7 years. Piecewise mixed-effects models, overall and stratified by race and sex, were fit to assess differential growth patterns across age by maternal PHIV status. RESULTS: One thousand four hundred fifty-four singleton infants (286 CHEU-PHIV and 1168 CHEU-NPHIV) were included. CHEU-PHIV had slower growth rates than CHEU-NPHIV for WTZ and WLZ/BMIZ at earlier ages and continued to have lower mean WTZ [-0.27, 95% confidence interval (95% CI): -0.50, -0.04] and WLZ/BMIZ (-0.39, 95% CI: -0.67, -0.11) through age 7. Among non-Black boys, CHEU-PHIV had slightly lower WTZ and WLZ/BMIZ at birth than CHEU-NPHIV and these growth deficits persisted through age 7 years. CONCLUSION: Compared with CHEU-NPHIV, CHEU-PHIV had diminished growth in early childhood with differences most pronounced among non-Black male children. Further longitudinal follow-up of CHEU-PHIV into young adulthood is needed to understand whether these early effects of maternal PHIV status on growth persist and have other health consequences.
OBJECTIVE: The aim of this study was to compare long-term growth between HIV-exposed uninfected children (CHEU) born to women with perinatally acquired HIV (CHEU-PHIV) and CHEU born to women with nonperinatally acquired HIV (CHEU-NPHIV). DESIGN: A longitudinal analysis of anthropometric measurements from a U.S.-based multisite prospective cohort study enrolling CHEU and their mothers since April 2007. METHODS: CHEU were evaluated for growth annually from birth through age 5 and again at age 7 years. Z-scores were calculated using U.S. growth references for weight (WTZ), height (HTZ), and weight-for-length or BMI-for-age (WLZ/BMIZ). Mid-upper arm circumference (MUACZ) and triceps skinfold thickness (TSFZ) Z-scores were obtained from ages 1 and 2, respectively, through age 7 years. Piecewise mixed-effects models, overall and stratified by race and sex, were fit to assess differential growth patterns across age by maternal PHIV status. RESULTS: One thousand four hundred fifty-four singleton infants (286 CHEU-PHIV and 1168 CHEU-NPHIV) were included. CHEU-PHIV had slower growth rates than CHEU-NPHIV for WTZ and WLZ/BMIZ at earlier ages and continued to have lower mean WTZ [-0.27, 95% confidence interval (95% CI): -0.50, -0.04] and WLZ/BMIZ (-0.39, 95% CI: -0.67, -0.11) through age 7. Among non-Black boys, CHEU-PHIV had slightly lower WTZ and WLZ/BMIZ at birth than CHEU-NPHIV and these growth deficits persisted through age 7 years. CONCLUSION: Compared with CHEU-NPHIV, CHEU-PHIV had diminished growth in early childhood with differences most pronounced among non-Black male children. Further longitudinal follow-up of CHEU-PHIV into young adulthood is needed to understand whether these early effects of maternal PHIV status on growth persist and have other health consequences.
Authors: George K Siberry; Paige L Williams; Hermann Mendez; George R Seage; Denise L Jacobson; Rohan Hazra; Kenneth C Rich; Raymond Griner; Katherine Tassiopoulos; Deborah Kacanek; Lynne M Mofenson; Tracie Miller; Linda A DiMeglio; D Heather Watts Journal: AIDS Date: 2012-06-01 Impact factor: 4.177
Authors: Russell B Van Dyke; Ellen Gould Chadwick; Rohan Hazra; Paige L Williams; George R Seage Journal: Front Immunol Date: 2016-05-23 Impact factor: 7.561
Authors: A Judd; R Lodwick; A Noguera-Julian; D M Gibb; K Butler; D Costagliola; C Sabin; A van Sighem; B Ledergerber; C Torti; A Mocroft; D Podzamczer; M Dorrucci; S De Wit; N Obel; F Dabis; A Cozzi-Lepri; F García; N H Brockmeyer; J Warszawski; M I Gonzalez-Tome; C Mussini; G Touloumi; R Zangerle; J Ghosn; A Castagna; G Fätkenheuer; C Stephan; L Meyer; M A Campbell; G Chene; A Phillips Journal: HIV Med Date: 2016-09-14 Impact factor: 3.180