Literature DB >> 3485526

Defective neutrophil chemotaxis in patients with alpha-1-antitrypsin deficiency.

A J Khan, H E Evans, M M Agbayani.   

Abstract

The PMNs of five infants and children with homozygous alpha-1-antitrypsin deficiency (PiZZ phenotype) revealed defective chemotactic migration, and their PiZZ sera generated a higher quantity of chemotactic factor(s). This defect(s) might have been responsible for the increased incidence of infections found in our deficient PiZZ patients. Further studies are needed to clarify the role of defective chemotaxis in the pathogenesis of chronic lung disease associated with the PiZZ state.

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Year:  1986        PMID： 3485526     DOI： 10.1007/BF00441739

Source DB:  PubMed          Journal:  Eur J Pediatr        ISSN： 0340-6199            Impact factor:   3.183


  11 in total

1.  Complement studies in alpha-1-antitrypsin deficiency in children.

Authors:  C Le Prévost; D Frommel; J M Dupuy
Journal:  J Pediatr       Date:  1975-10       Impact factor: 4.406

2.  Defective neutrophil chemotaxis in patients with Down syndrome.

Authors:  A J Khan; H E Evans; L Glass; Y H Skin; D Almonte
Journal:  J Pediatr       Date:  1975-07       Impact factor: 4.406

Review 3.  alpha1-antitrypsin deficiency (first of two parts).

Authors:  J O Morse
Journal:  N Engl J Med       Date:  1978-11-09       Impact factor: 91.245

Review 4.  Alpha1-antitrypsin deficiency (second of two parts).

Authors:  J O Morse
Journal:  N Engl J Med       Date:  1978-11-16       Impact factor: 91.245

5.  The polymorphism of "prealbumins" and alpha-1-antitrypsin in human sera.

Authors:  M K Fagerhol; C B Laurell
Journal:  Clin Chim Acta       Date:  1967-05       Impact factor: 3.786

6.  alpha 1-antitrypsin deficiency in early childhood.

Authors:  T Sveger
Journal:  Pediatrics       Date:  1978-07       Impact factor: 7.124

7.  Defective regulation of chemotaxis in cirrhosis.

Authors:  E C Maderazo; P A Ward; R Quintiliani
Journal:  J Lab Clin Med       Date:  1975-04

8.  Deficiency of the chemotactic factor inactivator in human sera with 1 -antitrypsin deficiency.

Authors:  P A Ward; R C Talamo
Journal:  J Clin Invest       Date:  1973-02       Impact factor: 14.808

9.  Abnormal neutrophil chemotaxis and random migration induced by aminoglycoside antibiotics.

Authors:  A J Khan; H E Evans; L Glass; P Khan; C T Chang; S R Nair
Journal:  J Lab Clin Med       Date:  1979-02

10.  The deactivation of rabbit neutrophils by chemotactic factor and the nature of the activatable esterase.

Authors:  P A Ward; E L Becker
Journal:  J Exp Med       Date:  1968-04-01       Impact factor: 14.307
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  2 in total

Review 1.  Lung disease associated with alpha1-antitrypsin deficiency.

Authors:  Rubin M Tuder; Sabina M Janciauskiene; Irina Petrache
Journal:  Proc Am Thorac Soc       Date:  2010-11

2.  Neutrophil Fates in Bronchiectasis and Alpha-1 Antitrypsin Deficiency.

Authors:  Derek W Russell; Amit Gaggar; George M Solomon
Journal:  Ann Am Thorac Soc       Date:  2016-04
  2 in total

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