Literature DB >> 34855083

Improved Survival and Regeneration of Irradiated Mouse Neural Stem Cells after Co-Culturing with Non-Irradiated Mouse Neural Stem Cells or Mesenchymal Stem Cells from the Adipose Tissue.

M G Ratushnyak1, Yu P Semochkina2, A S Zhirnik2, O D Smirnova2.   

Abstract

We studied the effect of neural stem cells (NSC) and mesenchymal stem cells (MSC) from mouse adipose tissue on survival, clonogenic activity, and senescence of NSC after exposure to γ-radiation. It was found that survival and clonogenic activity of NSC irradiated in doses of 1 and 2 Gy was enhanced when irradiated cells were co-cultured with non-irradiated NSC and MSC in permeable Transwell inserts. The proportion of senescent NSC (cells with high β-galactosidase activity) increased with increasing irradiation dose. Co-culturing with non-irradiated NSC in 3 days after irradiation in a dose of 1 Gy led to a decrease in the proportion of senescent cells among irradiated NSC. Factors secreted by NSC and MSC can become the basis for the development of means for prevention and treatment of damage to brain cells resulting from radiation therapy of head and neck cancer.
© 2021. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  cell therapy; mesenchymal stem cells; neural stem cells; senescence; γ-radiation

Mesh：

Year:  2021        PMID： 34855083     DOI： 10.1007/s10517-021-05368-0

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  22 in total

1.  Defining the optimal window for cranial transplantation of human induced pluripotent stem cell-derived cells to ameliorate radiation-induced cognitive impairment.

Authors:  Munjal M Acharya; Vahan Martirosian; Lori-Ann Christie; Lara Riparip; Jan Strnadel; Vipan K Parihar; Charles L Limoli
Journal:  Stem Cells Transl Med       Date:  2014-11-12       Impact factor: 6.940

Review 2.  Stem cell-based therapy for experimental stroke: a systematic review and meta-analysis.

Authors:  Jennifer S Lees; Emily S Sena; Kieren J Egan; Ana Antonic; Simon A Koblar; David W Howells; Malcolm R Macleod
Journal:  Int J Stroke       Date:  2012-06-12       Impact factor: 5.266

Review 3.  Cellular senescence: when bad things happen to good cells.

Authors:  Judith Campisi; Fabrizio d'Adda di Fagagna
Journal:  Nat Rev Mol Cell Biol       Date:  2007-09       Impact factor: 94.444

4.  Adipose-derived stem cell-conditioned medium protects fibroblasts at different senescent degrees from UVB irradiation damages.

Authors:  Shu Guo; Ting Wang; Shuangyi Zhang; Peng Chen; Zheng Cao; Wenqin Lian; Jiayan Guo; Yue Kang
Journal:  Mol Cell Biochem       Date:  2019-10-10       Impact factor: 3.396

Review 5.  Stem cell paracrine actions and tissue regeneration.

Authors:  Priya R Baraniak; Todd C McDevitt
Journal:  Regen Med       Date:  2010-01       Impact factor: 3.806

6.  Transplantation of human fetal-derived neural stem cells improves cognitive function following cranial irradiation.

Authors:  Munjal M Acharya; Lori-Ann Christie; Thomas G Hazel; Karl K Johe; Charles L Limoli
Journal:  Cell Transplant       Date:  2013-07-17       Impact factor: 4.064

7.  Adipose-derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitis.

Authors:  Gabriela Constantin; Silvia Marconi; Barbara Rossi; Stefano Angiari; Laura Calderan; Elena Anghileri; Beatrice Gini; Simone Dorothea Bach; Marianna Martinello; Francesco Bifari; Mirco Galiè; Ermanna Turano; Simona Budui; Andrea Sbarbati; Mauro Krampera; Bruno Bonetti
Journal:  Stem Cells       Date:  2009-10       Impact factor: 6.277

8.  Human neural stem cell transplantation provides long-term restoration of neuronal plasticity in the irradiated hippocampus.

Authors:  Munjal M Acharya; Susanna Rosi; Timothy Jopson; Charles L Limoli
Journal:  Cell Transplant       Date:  2014-10-06       Impact factor: 4.064

Review 9.  The stem cell secretome and its role in brain repair.

Authors:  Denise Drago; Chiara Cossetti; Nunzio Iraci; Edoardo Gaude; Giovanna Musco; Angela Bachi; Stefano Pluchino
Journal:  Biochimie       Date:  2013-07-01       Impact factor: 4.079

Review 10.  Senolytic drugs: from discovery to translation.

Authors:  J L Kirkland; T Tchkonia
Journal:  J Intern Med       Date:  2020-08-04       Impact factor: 13.068
View more
  2 in total

1.  Stem Cell Exosomes Improve Survival of Neural Stem Cells after Radiation Exposure.

Authors:  M G Ratushnyak; Yu P Semochkina; E V Yastremsky; R A Kamyshinsky
Journal:  Bull Exp Biol Med       Date:  2022-09-05       Impact factor: 0.737

Review 2.  Interaction of Neural Stem Cells (NSCs) and Mesenchymal Stem Cells (MSCs) as a Promising Approach in Brain Study and Nerve Regeneration.

Authors:  Agnieszka Kaminska; Klaudia Radoszkiewicz; Paulina Rybkowska; Aleksandra Wedzinska; Anna Sarnowska
Journal:  Cells       Date:  2022-04-26       Impact factor: 7.666
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.