Literature DB >> 34855080

Experimental Study of the Efficacy of Sodium Deoxyribonucleate Used in Combination with Co-Transplantation of Mesenchymal and Hematopoietic Stem Cells after Exposure to γ-Radiation.

L N Pavlova1, L P Zhavoronkov2, V V Pavlov3, V V Panfilova2, O S Izmest'eva2, O F Chibisova2, V L Ivanov2, P V Shegai4, A D Kaprin4,5.   

Abstract

We studied the possibility of using sodium deoxyribonucleate (Derinat) for improving the efficiency of co-transplantation of mesenchymal (MSC) and hematopoietic stem cells (HSC) to female F1(CBA×C57BL/6) mice with bone marrow aplasia caused by exposure to γ-radiation. It was found that immunomodulator Derinat enhanced the effect of co-transplantation, in particular, triple post-irradiation administration of Derinat accelerated hematopoiesis recovery judging from the parameters of peripheral blood, total cellularity of the bone marrow and spleen, and animal survival. Single or double administration of Derinat prior to irradiation was ineffective. The optimal result was obtained when the following scheme was applied: MSC→HSC with an interval of 48 h starting during the first hours after irradiation and triple administration of Derinat (in 10-15 min, 3 and 7 days after irradiation) in a dose of 3 mg/mouse.
© 2021. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  co-transplantation; hemopoiesis; linear mice; sodium deoxyribonucleate; stem cells

Mesh：

Substances：

Year:  2021        PMID： 34855080     DOI： 10.1007/s10517-021-05369-z

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  10 in total

1.  Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice.

Authors:  Maria Angelopoulou; Enrico Novelli; Joanna E Grove; Henry M Rinder; Curt Civin; Linzhao Cheng; Diane S Krause
Journal:  Exp Hematol       Date:  2003-05       Impact factor: 3.084

2.  Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy.

Authors:  O N Koç; S L Gerson; B W Cooper; S M Dyhouse; S E Haynesworth; A I Caplan; H M Lazarus
Journal:  J Clin Oncol       Date:  2000-01       Impact factor: 44.544

Review 3.  Regulation of hematopoietic stem cell self-renewal.

Authors:  Tannishtha Reya
Journal:  Recent Prog Horm Res       Date:  2003

4.  Morphofunctional study of the therapeutic efficacy of human mesenchymal and neural stem cells in rats with diffuse brain injury.

Authors:  A F Tsyb; V V Yuzhakov; L M Roshal'; G T Sukhikh; A G Konoplyannikov; G N Sushkevich; N D Yakovleva; I E Ingel'; L N Bandurko; L E Sevan'kaeva; L N Mikhina; N K Fomina; M V Marei; Zh B Semenova; O A Konoplyannikova; S Sh Kal'sina; L A Lepekhina; I V Semenkova; E V Agaeva; A S Shevchuk; L N Pavlova; O Yu Tokarev; O V Karaseva; T A Chernyshova
Journal:  Bull Exp Biol Med       Date:  2009-01       Impact factor: 0.804

5.  Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients.

Authors:  Hillard M Lazarus; Omer N Koc; Steven M Devine; Peter Curtin; Richard T Maziarz; H Kent Holland; Elizabeth J Shpall; Philip McCarthy; Kerry Atkinson; Brenda W Cooper; Stanton L Gerson; Mary J Laughlin; Fausto R Loberiza; Annemarie B Moseley; Andrea Bacigalupo
Journal:  Biol Blood Marrow Transplant       Date:  2005-05       Impact factor: 5.742

6.  Effect of Different Regimens of Co-Transplantation of Hemopoietic and Mesenchymal Hemopoietic Stem Cells on the Rates of Hemopoietic Recovery in Laboratory Mice Treated with Cyclophosphamide in Sublethal Doses.

Authors:  V V Pavlov; L N Pavlova; O F Chibisova; V L Ivanov; E I Selivanova; A G Konoplyannikov; L P Zhavoronkov
Journal:  Bull Exp Biol Med       Date:  2019-02-19       Impact factor: 0.804

7.  Muscle regeneration by bone marrow-derived myogenic progenitors.

Authors:  G Ferrari; G Cusella-De Angelis; M Coletta; E Paolucci; A Stornaiuolo; G Cossu; F Mavilio
Journal:  Science       Date:  1998-03-06       Impact factor: 47.728

8.  Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells.

Authors:  K Le Blanc; H Samuelsson; B Gustafsson; M Remberger; B Sundberg; J Arvidson; P Ljungman; H Lönnies; S Nava; O Ringdén
Journal:  Leukemia       Date:  2007-05-31       Impact factor: 11.528

9.  Hematopoietic stem cells are uniquely selective in their migratory response to chemokines.

Authors:  Douglas E Wright; Edward P Bowman; Amy J Wagers; Eugene C Butcher; Irving L Weissman
Journal:  J Exp Med       Date:  2002-05-06       Impact factor: 14.307

10.  Pim1 kinase regulates c-Kit gene translation.

Authors:  Ningfei An; Bo Cen; Houjian Cai; Jin H Song; Andrew Kraft; Yubin Kang
Journal:  Exp Hematol Oncol       Date:  2016-12-30
  10 in total

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