Literature DB >> 19526149

Morphofunctional study of the therapeutic efficacy of human mesenchymal and neural stem cells in rats with diffuse brain injury.

A F Tsyb1, V V Yuzhakov, L M Roshal', G T Sukhikh, A G Konoplyannikov, G N Sushkevich, N D Yakovleva, I E Ingel', L N Bandurko, L E Sevan'kaeva, L N Mikhina, N K Fomina, M V Marei, Zh B Semenova, O A Konoplyannikova, S Sh Kal'sina, L A Lepekhina, I V Semenkova, E V Agaeva, A S Shevchuk, L N Pavlova, O Yu Tokarev, O V Karaseva, T A Chernyshova.   

Abstract

We studied the effect of transplantation of human stem cells from various tissues on reparative processes in the brain of rats with closed craniocerebral injury. Combined treatment with standard drugs and systemic administration of xenogeneic stem cells had a neuroprotective effect. The morphology of neurons rapidly returned to normal after administration of fetal neural stem cells. Fetal mesenchymal stem cells produced a prolonged effect on proliferative activity of progenitor cells in the subventricular zone of neurogenesis. Adult mesenchymal stem cells had a strong effect on recovery of the vascular bed in ischemic regions.

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Year:  2009        PMID： 19526149     DOI： 10.1007/s10517-009-0432-3

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  4 in total

1.  Amelioration of Penetrating Ballistic-Like Brain Injury Induced Cognitive Deficits after Neuronal Differentiation of Transplanted Human Neural Stem Cells.

Authors:  Markus S Spurlock; Aminul I Ahmed; Karla N Rivera; Shoji Yokobori; Stephanie W Lee; Pingdewinde N Sam; Deborah A Shear; Michael P Hefferan; Thomas G Hazel; Karl K Johe; Shyam Gajavelli; Frank C Tortella; Ross M Bullock
Journal:  J Neurotrauma       Date:  2017-03-23       Impact factor: 5.269

2.  The effect of Semax and its C-end peptide PGP on the morphology and proliferative activity of rat brain cells during experimental ischemia: a pilot study.

Authors:  Vasily V Stavchansky; Vadim V Yuzhakov; Alexandra Yu Botsina; Veronika I Skvortsova; Lyubov N Bondurko; Marina G Tsyganova; Svetlana A Limborska; Nikolay F Myasoedov; Lyudmila V Dergunova
Journal:  J Mol Neurosci       Date:  2010-07-09       Impact factor: 3.444

3.  Transplantation of Mesenchymal Stromal Cells in Patients With Amyotrophic Lateral Sclerosis: Results of Phase I/IIa Clinical Trial.

Authors:  Eva Syková; Petr Rychmach; Ivana Drahorádová; Šimona Konrádová; Kateřina Růžičková; Ivan Voříšek; Serhiy Forostyak; Aleš Homola; Martin Bojar
Journal:  Cell Transplant       Date:  2016-11-07       Impact factor: 4.064

4.  Experimental Study of the Efficacy of Sodium Deoxyribonucleate Used in Combination with Co-Transplantation of Mesenchymal and Hematopoietic Stem Cells after Exposure to γ-Radiation.

Authors:  L N Pavlova; L P Zhavoronkov; V V Pavlov; V V Panfilova; O S Izmest'eva; O F Chibisova; V L Ivanov; P V Shegai; A D Kaprin
Journal:  Bull Exp Biol Med       Date:  2021-12-02       Impact factor: 0.804
  4 in total

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