| Literature DB >> 34853965 |
N V Tursunova1, V N Syrov2, Z A Khushbaktova2, Yu V Tornuev3, M G Klinnikova3.
Abstract
We analyzed changes in activities of enzymes of phases I and II of xenobiotic biotransformation and parameters of NO metabolism in liver microsomes of rats with toxic CCl4-induced hepatitis after a 14-day course of sesquiterpene lactones from Artemisia leucodes (10 mg/kg). It was found that toxic hepatitis was associated with significant inhibition of NADPH-cytochrome c-reductase, benzo(a)pyrene hydroxylase, and NADPH-diaphorase, reduced cytochrome P-450 content, and enhanced induction of nitrate/nitrite reductase with accumulation of NO metabolites in the liver. Administration of sesquiterpene lactones stimulated activity of the studied components of the cytochrome P-450 system and promoted recovery of the NOergic system components; the effects were most pronounced in 7 and 14 days after treatment.Entities:
Keywords: cytochrome P-450; liver microsomes; nitric oxide system, sesquiterpene lactones; toxic hepatitis
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Year: 2021 PMID： 34853965 DOI： 10.1007/s10517-021-05349-3
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804