Literature DB >> 26027855

Nitric oxide in liver diseases.

Yasuko Iwakiri1, Moon Young Kim2.   

Abstract

Nitric oxide (NO) and its derivatives play important roles in the physiology and pathophysiology of the liver. Despite its diverse and complicated roles, certain patterns of the effect of NO on the pathogenesis and progression of liver diseases are observed. In general, NO derived from endothelial NO synthase (eNOS) in liver sinusoidal endothelial cells (LSECs) is protective against disease development, while inducible NOS (iNOS)-derived NO contributes to pathological processes. This review addresses the roles of NO in the development of various liver diseases with a focus on recently published articles. We present here two recent advances in understanding NO-mediated signaling - nitrated fatty acids (NO2-FAs) and S-guanylation - and conclude with suggestions for future directions in NO-related studies on the liver.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  eNOS; endothelial cells; iNOS; inflammation; portal hypertension

Mesh：

Substances：

Year:  2015        PMID： 26027855      PMCID： PMC4532625          DOI： 10.1016/j.tips.2015.05.001

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  167 in total

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