Cailin Ding1, Zengmeng Wang1, Chunhui Peng1, Wenbo Pang1, Sarah Siyin Tan1, Yajun Chen2. 1. Department of General Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nanlishi Road, Xicheng District, Beijing, 100045, People's Republic of China. 2. Department of General Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nanlishi Road, Xicheng District, Beijing, 100045, People's Republic of China. chenyajunmd@aliyun.com.
Abstract
PURPOSE: To evaluate the application value of two-dimensional shear wave elastography (2D-SWE) for non-invasive diagnosis of liver cirrhosis (LC) in patients with biliary atresia (BA) before Kasai portoenterostomy (KP), and the cutoff value of liver stiffness measurement (LSM) for diagnosing LC. METHODS: The clinical data of 51 patients with BA who were diagnosed via surgery and pathological results from May 2017 to December 2018 in the department of general surgery, Beijing Children's Hospital, Capital Medical University, were retrospectively analyzed. The liver tissue specimens obtained during KP were evaluated according to the METAVIR criteria. The LSM was obtained using the 2D-SWE technique before KP. RESULTS: There was a grade positive correlation between LSM and METAVIR staging, and the Spearman correlation coefficient was 0.432 (P = 0.002). The AUC for 2D-SWE diagnosing LC (METAVIR score S = 4) in patients with BA before KP was 0.843 (95% confidence interval 0.736 ~ 0.950). The best cutoff value was 16.05 kPa, and the corresponding sensitivity was 75.0%, specificity was 83.7%, positive predictive value (PPV) was 46.1%, negative predictive value (NPV) was 94.7%, and the accuracy was 82.4%. CONCLUSION: 2D-SWE can be used to noninvasively diagnose LC in patients with BA before KP, and the cutoff value is 16.05 kPa.
PURPOSE: To evaluate the application value of two-dimensional shear wave elastography (2D-SWE) for non-invasive diagnosis of liver cirrhosis (LC) in patients with biliary atresia (BA) before Kasai portoenterostomy (KP), and the cutoff value of liver stiffness measurement (LSM) for diagnosing LC. METHODS: The clinical data of 51 patients with BA who were diagnosed via surgery and pathological results from May 2017 to December 2018 in the department of general surgery, Beijing Children's Hospital, Capital Medical University, were retrospectively analyzed. The liver tissue specimens obtained during KP were evaluated according to the METAVIR criteria. The LSM was obtained using the 2D-SWE technique before KP. RESULTS: There was a grade positive correlation between LSM and METAVIR staging, and the Spearman correlation coefficient was 0.432 (P = 0.002). The AUC for 2D-SWE diagnosing LC (METAVIR score S = 4) in patients with BA before KP was 0.843 (95% confidence interval 0.736 ~ 0.950). The best cutoff value was 16.05 kPa, and the corresponding sensitivity was 75.0%, specificity was 83.7%, positive predictive value (PPV) was 46.1%, negative predictive value (NPV) was 94.7%, and the accuracy was 82.4%. CONCLUSION: 2D-SWE can be used to noninvasively diagnose LC in patients with BA before KP, and the cutoff value is 16.05 kPa.
Authors: Esteban P Dardanelli; Maria Eugenia Orozco; Juliana Lostra; Clarisa Laprida; Solange Lulkin; Andrea P Bosaleh; Carolina Cernadas; José E Lipsich Journal: Pediatr Radiol Date: 2020-02-18
Authors: Eva Herrmann; Victor de Lédinghen; Christophe Cassinotto; Winnie C-W Chu; Vivian Y-F Leung; Giovanna Ferraioli; Carlo Filice; Laurent Castera; Valérie Vilgrain; Maxime Ronot; Jérôme Dumortier; Aymeric Guibal; Stanislas Pol; Jonel Trebicka; Christian Jansen; Christian Strassburg; Rongqin Zheng; Jian Zheng; Sven Francque; Thomas Vanwolleghem; Luisa Vonghia; Emanuel K Manesis; Pavlos Zoumpoulis; Ioan Sporea; Maja Thiele; Aleksander Krag; Claude Cohen-Bacrie; Aline Criton; Joel Gay; Thomas Deffieux; Mireen Friedrich-Rust Journal: Hepatology Date: 2017-11-15 Impact factor: 17.425