Nia McRae1, Chris Gennings1, Nadya Rivera Rivera1, Marcela Tamayo-Ortiz2, Ivan Pantic3, Chitra Amarasiriwardena1, Lourdes Schnaas3, Rosalind Wright4, Martha M Tellez-Rojo5, Robert O Wright6, Maria José Rosa7. 1. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 2. Occupational Health Research Unit, Mexican Institute of Social Security (IMSS), Mexico City, Mexico. 3. Department of Developmental Neurobiology, National Institute of Perinatology, Mexico City, Mexico. 4. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Kravis Children's Hospital, Department of Pediatrics, Division of Pediatric Pulmonology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 5. Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico. 6. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 7. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: maria.rosa@mssm.edu.
Abstract
INTRODUCTION: Manganese and lead have been cross-sectionally associated with adverse respiratory outcomes in childhood but there is limited data on their combined effects starting in utero. We examined associations between in utero exposure to metals and childhood respiratory symptoms. METHODS: We assessed 633 mother-child dyads enrolled in the Programming Research in Obesity, Growth, Environment, and Social Stressors (PROGRESS) birth cohort in Mexico City. Blood manganese (BMn) and lead (BPb) were measured in mothers at 2nd and 3rd trimester. Ever wheeze, current wheeze and asthma diagnosis were ascertained at 4-5 and 6-7 year visits through the International Study of Asthma and Allergies in Childhood survey. Logistic mixed model regression was used to assess the association between prenatal metals and respiratory outcomes in children across the 4-5 and 6-7 year visits. Covariates included mother's age, education and asthma, environmental tobacco smoke, child's sex and assessment time. RESULTS: In adjusted models, higher 2nd trimester BPb had a significant association with elevated odds of ever wheeze (Odds Ratio (OR): 1.97, 95% CI: 1.05, 3.67). BMn at 2nd trimester was associated with decreased (OR: 0.06, 95% CI: 0.01, 0.35) odds of current wheeze. We did not find any statistically significant associations with 3rd trimester blood metals. CONCLUSION: Prenatal exposure to Pb was associated with higher odds of ever wheeze while Mn was negatively associated with odds of current wheeze. These findings underscore the need to consider prenatal metal exposure, including low exposure levels, in the study of adverse respiratory outcomes.
INTRODUCTION: Manganese and lead have been cross-sectionally associated with adverse respiratory outcomes in childhood but there is limited data on their combined effects starting in utero. We examined associations between in utero exposure to metals and childhood respiratory symptoms. METHODS: We assessed 633 mother-child dyads enrolled in the Programming Research in Obesity, Growth, Environment, and Social Stressors (PROGRESS) birth cohort in Mexico City. Blood manganese (BMn) and lead (BPb) were measured in mothers at 2nd and 3rd trimester. Ever wheeze, current wheeze and asthma diagnosis were ascertained at 4-5 and 6-7 year visits through the International Study of Asthma and Allergies in Childhood survey. Logistic mixed model regression was used to assess the association between prenatal metals and respiratory outcomes in children across the 4-5 and 6-7 year visits. Covariates included mother's age, education and asthma, environmental tobacco smoke, child's sex and assessment time. RESULTS: In adjusted models, higher 2nd trimester BPb had a significant association with elevated odds of ever wheeze (Odds Ratio (OR): 1.97, 95% CI: 1.05, 3.67). BMn at 2nd trimester was associated with decreased (OR: 0.06, 95% CI: 0.01, 0.35) odds of current wheeze. We did not find any statistically significant associations with 3rd trimester blood metals. CONCLUSION: Prenatal exposure to Pb was associated with higher odds of ever wheeze while Mn was negatively associated with odds of current wheeze. These findings underscore the need to consider prenatal metal exposure, including low exposure levels, in the study of adverse respiratory outcomes.
Authors: Bert B Little; Zofia Ignasiak; Teresa Sławinska; Pawel Posłuszny; R M Malina; David L Wiegman Journal: Ann Hum Biol Date: 2017-10-30 Impact factor: 1.533
Authors: Martha María Téllez-Rojo; Luis F Bautista-Arredondo; Belem Trejo-Valdivia; Alejandra Cantoral; Daniel Estrada-Sánchez; Ruben Kraiem; Ivan Pantic; Antonio Rosa-Parra; Luz María Gómez-Acosta; Martín Romero-Martínez; Lucía Cuevas-Nasu; Teresa Shamah-Levy; Richard Fuller; Marcela Tamayo-Ortiz Journal: Salud Publica Mex Date: 2019 Nov-Dic
Authors: Emily F Winterbottom; Yuka Moroishi; Yuliya Halchenko; David A Armstrong; Paul J Beach; Quang P Nguyen; Anthony J Capobianco; Nagi G Ayad; Carmen J Marsit; Zhigang Li; Margaret R Karagas; David J Robbins Journal: Environ Health Date: 2019-02-28 Impact factor: 5.984