Literature DB >> 3484645

(11; 14) translocation in three boys with acute lymphoblastic leukemia of T-cell immunophenotype.

J Harbott, R Engel, V Gerein, D Schwamborn, R Rudolph, F Lampert.   

Abstract

Three boys, 12, 15 and 5 years old are presented with acute lymphoblastic leukemia resp. Non-Hodgkin's lymphoma with leukemic transformation. Blast cells could be characterized as being of T-cell origin. Hand mirror variant was the predominant morphologic feature of the blast cells in two patients. Chromosome analysis of the leukemic blast cells revealed a pseudodiploid (modal chromosome number = 46) karyotype in two patients and a pseudotetraploid (modal chromosome number = 92) in one patient. A chromosome translocation (11; 14) with breakpoints at (p 13; q 13) (within the human T-cell receptor alpha chain locus!) was found in the leukemic cells of all three cases plus an additional t (7; 9) (q 22; p 13) in one patient.

Entities:  

Mesh：

Year:  1986        PMID： 3484645     DOI： 10.1007/BF00320141

Source DB:  PubMed          Journal:  Blut        ISSN： 0006-5242


  18 in total

1.  Abnormalities of chromosome 14 at band 14q11 in Japanese patients with adult T-cell leukemia.

Authors:  N Sadamori; M Kusano; K Nishino; M Tagawa; E Yao; Y Yamada; T Amagasaki; K Kinoshita; M Ichimaru
Journal:  Cancer Genet Cytogenet       Date:  1985-07

2.  The role of gene dosage and genetic transpositions in carcinogenesis.

Authors:  G Klein
Journal:  Nature       Date:  1981-11-26       Impact factor: 49.962

3.  Correlation of karyotype with clinical features in acute lymphoblastic leukemia.

Authors:  Y Kaneko; J D Rowley; D Variakojis; R R Chilcote; I Check; M Sakurai
Journal:  Cancer Res       Date:  1982-07       Impact factor: 12.701

4.  Common region on chromosome 14 in T-cell leukemia and lymphoma.

Authors:  F Hecht; R Morgan; B K Hecht; S D Smith
Journal:  Science       Date:  1984-12-21       Impact factor: 47.728

5.  Cytogenetic findings in childhood acute lymphoblastic leukemia.

Authors:  J R Kowalczyk; M Grossi; A A Sandberg
Journal:  Cancer Genet Cytogenet       Date:  1985-02-01

6.  The c-Ha-ras1, insulin and beta-globin loci map outside the deletion associated with aniridia-Wilms' tumour.

Authors:  B de Martinville; U Francke
Journal:  Nature       Date:  1983 Oct 13-19       Impact factor: 49.962

7.  [BFM study 1981/83 of the treatment of highly malignant non-Hodgkin's lymphoma in children: results of therapy stratified according to histologic immunological type and clinical stage].

Authors:  S Müller-Weihrich; J Beck; G Henze; A Jobke; B Kornhuber; F Lampert; R Ludwig; G Prindull; G Schellong; H J Spaar
Journal:  Klin Padiatr       Date:  1984 May-Jun       Impact factor: 1.349

Review 8.  Significance of chromosome change to hematopoietic neoplasms.

Authors:  R S Chaganti
Journal:  Blood       Date:  1983-09       Impact factor: 22.113

9.  Gene for alpha-chain of human T-cell receptor: location on chromosome 14 region involved in T-cell neoplasms.

Authors:  C M Croce; M Isobe; A Palumbo; J Puck; J Ming; D Tweardy; J Erikson; M Davis; G Rovera
Journal:  Science       Date:  1985-03-01       Impact factor: 47.728

10.  Human T-cell receptor alpha-chain genes: location on chromosome 14.

Authors:  C Jones; H G Morse; F T Kao; A Carbone; E Palmer
Journal:  Science       Date:  1985-04-05       Impact factor: 47.728
View more
  5 in total

1.  Molecular cloning of the translocation breakpoint in T-ALL 11;14 (p13;q11): genomic map of TCR alpha and delta region on chromosome 14q11 and long-range map of region 11p13.

Authors:  B Royer-Pokora; B Fleischer; S Ragg; U Loos; D Williams
Journal:  Hum Genet       Date:  1989-06       Impact factor: 4.132

Review 2.  Genetic and cytogenetic changes in acute lymphoblastic leukemia.

Authors:  H G Ahuja; M J Cline
Journal:  Med Oncol Tumor Pharmacother       Date:  1988

3.  Acute leukemia with chromosome translocation (4;11): 7 new patients and analysis of 71 cases.

Authors:  F Lampert; J Harbott; W D Ludwig; C R Bartram; J Ritter; V Gerein; M Neidhardt; R Mertens; N Graf; H Riehm
Journal:  Blut       Date:  1987-06

4.  T-cell acute childhood lymphoblastic leukemia with chromosome 14 q 11 anomaly: a morphologic, immunologic, and cytogenetic analysis of 10 patients.

Authors:  F Lampert; J Harbott; J Ritterbach; W D Ludwig; C Fonatsch; D Schwamborn; B Stier; A Gnekow; V Gerein; B Stollmann
Journal:  Blut       Date:  1988-03

5.  The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor C delta locus on human chromosome 14q11 and a transcribed region of chromosome 11p15.

Authors:  T Boehm; R Baer; I Lavenir; A Forster; J J Waters; E Nacheva; T H Rabbitts
Journal:  EMBO J       Date:  1988-02       Impact factor: 11.598
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.