PURPOSE: To perform fast 3D steady-state CEST (ss-CEST) imaging using MR Multitasking. METHODS: A continuous acquisition sequence with repetitive ss-CEST modules was developed. Each ss-CEST module contains a single-lobe Gaussian saturation pulse, followed by a spoiler gradient and eight FLASH readouts (one "training line" + seven "imaging lines"). Three-dimensional Cartesian encoding was used for k-space acquisition. Reconstructed CEST images were quantified with four-pool Lorentzian fitting. RESULTS: Steady-state CEST with whole-brain coverage was performed in 5.6 s per saturation frequency offset at the spatial resolution of 1.7 × 1.7 × 3.0 mm3 . The total scan time was 5.5 min for 55 different frequency offsets. Quantitative CEST maps from multipool fitting showed consistent image quality across the volume. CONCLUSION: Three-dimensional ss-CEST with whole-brain coverage can be done at 3 T within 5.5 min using MR Multitasking.
PURPOSE: To perform fast 3D steady-state CEST (ss-CEST) imaging using MR Multitasking. METHODS: A continuous acquisition sequence with repetitive ss-CEST modules was developed. Each ss-CEST module contains a single-lobe Gaussian saturation pulse, followed by a spoiler gradient and eight FLASH readouts (one "training line" + seven "imaging lines"). Three-dimensional Cartesian encoding was used for k-space acquisition. Reconstructed CEST images were quantified with four-pool Lorentzian fitting. RESULTS: Steady-state CEST with whole-brain coverage was performed in 5.6 s per saturation frequency offset at the spatial resolution of 1.7 × 1.7 × 3.0 mm3 . The total scan time was 5.5 min for 55 different frequency offsets. Quantitative CEST maps from multipool fitting showed consistent image quality across the volume. CONCLUSION: Three-dimensional ss-CEST with whole-brain coverage can be done at 3 T within 5.5 min using MR Multitasking.
Authors: Mohammad Haris; Anup Singh; Kejia Cai; Feliks Kogan; Jeremy McGarvey; Catherine Debrosse; Gerald A Zsido; Walter R T Witschey; Kevin Koomalsingh; James J Pilla; Julio A Chirinos; Victor A Ferrari; Joseph H Gorman; Hari Hariharan; Robert C Gorman; Ravinder Reddy Journal: Nat Med Date: 2014-01-12 Impact factor: 53.440
Authors: Yang Zhou; Peter C M van Zijl; Xiang Xu; Jiadi Xu; Yuguo Li; Lin Chen; Nirbhay N Yadav Journal: Proc Natl Acad Sci U S A Date: 2020-01-30 Impact factor: 11.205
Authors: Mark Jenkinson; Christian F Beckmann; Timothy E J Behrens; Mark W Woolrich; Stephen M Smith Journal: Neuroimage Date: 2011-09-16 Impact factor: 6.556