Literature DB >> 3482108

Prolongation of life span of dystrophic hamster by cysteine proteinase inhibitor, loxistation (EST).

M Tamai1, S Omura, M Kimura, K Hanada, H Sugita.   

Abstract

We studied the effect of loxistation (EST), an orally applicable cysteine proteinase inhibitor, on dystrophic hamsters, UM-X7.1.E-64-c, an active form of EST, was continuously found in plasma when the feed containing EST was given ad libitum. The drug concentration in plasma of dystrophic hamsters receiving EST feed showed distinct dose dependency. A diet containing EST from weaning to death significantly prolonged the survival period of the dystrophic hamsters.

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Year:  1987        PMID： 3482108     DOI： 10.1248/bpb1978.10.678

Source DB:  PubMed          Journal:  J Pharmacobiodyn        ISSN： 0386-846X


  5 in total

1.  Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation.

Authors:  K Doh-Ura; T Iwaki; B Caughey
Journal:  J Virol       Date:  2000-05       Impact factor: 5.103

2.  Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors.

Authors:  Isaac T Schiefer; Subhasish Tapadar; Vladislav Litosh; Marton Siklos; Rob Scism; Gihani T Wijewickrama; Esala P Chandrasena; Vaishali Sinha; Ehsan Tavassoli; Michael Brunsteiner; Mauro Fa'; Ottavio Arancio; Pavel Petukhov; Gregory R J Thatcher
Journal:  J Med Chem       Date:  2013-07-22       Impact factor: 7.446

3.  Inhibition of cysteine proteinases in lysosomes and whole cells.

Authors:  D Wilcox; R W Mason
Journal:  Biochem J       Date:  1992-07-15       Impact factor: 3.857

4.  Antiviral effects of a thiol protease inhibitor on foot-and-mouth disease virus.

Authors:  L G Kleina; M J Grubman
Journal:  J Virol       Date:  1992-12       Impact factor: 5.103

Review 5.  Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate.

Authors:  Gregory Hook; J Steven Jacobsen; Kenneth Grabstein; Mark Kindy; Vivian Hook
Journal:  Front Neurol       Date:  2015-09-02       Impact factor: 4.003
  5 in total

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