| Literature DB >> 3481363 |
C P Steuber1, V J Land, C I Civin, A H Ragab, J Krischer, T J Vietti.
Abstract
To determine optimal dosage, Dihydroxyanthracenedione (DHAD) was given once daily for 3 days at dosage levels of 6, 7, 8, and 10 mg/m2 in combination with a 7-day continuous infusion of cytosine arabinoside (Ara-C). Nineteen of 20 children with leukemia who received these agents developed fever requiring hospitalization. There were 4 deaths-2 due to proven infection. One patient developed nonfatal cardiotoxicity. No other significant toxicity was noted. Responses were seen in 7 of 20 patients. The recommended DHAD dosage was 8 mg/m2/day when given in combination with Ara-C.Entities:
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Year: 1987 PMID： 3481363 DOI： 10.1007/BF00169979
Source DB: PubMed Journal: Invest New Drugs ISSN： 0167-6997 Impact factor: 3.850