Literature DB >> 239155

The interaction of aminoalkylaminoanthraquinones with deoxyribonucleic acid.

J C Double, J R Brown.   

Abstract

A series of aminoalkylaminoanthraquinones have been prepared as potential intercalating agents. The binding to DNA of these compounds and the known intercalating drugs chloroquine, lucanthone, daunorubicin and doxorubicin has been characterized by spectrophotometric titration. The association constant for the interaction with DNA has been determined for each compound from a Scatchard plot. The compounds synthesized had association constants between 0-5 and 4-2 times 10(6) compared with 0-93, 0-90, 3-10 and 2-49 times 10(6) for chloroquine, lucanthone, daunorubicin and doxorubicin respectively.

Entities:  

Mesh：

Substances：

Year:  1975        PMID： 239155     DOI： 10.1111/j.2042-7158.1975.tb09492.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  6 in total

1.  Pharmacology of mitoxantrone in cancer patients.

Authors:  N Savaraj; K Lu; V Manuel; T L Loo
Journal:  Cancer Chemother Pharmacol       Date:  1982       Impact factor: 3.333

2.  Toxicity evaluation of dihydroxyanthracenedione (DHAD) in combination with cytosine arabinoside (Ara-C).

Authors:  C P Steuber; V J Land; C I Civin; A H Ragab; J Krischer; T J Vietti
Journal:  Invest New Drugs       Date:  1987-12       Impact factor: 3.850

Review 3.  Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding agents: a new class of bioreductive agent.

Authors:  L H Patterson
Journal:  Cancer Metastasis Rev       Date:  1993-06       Impact factor: 9.264

4.  A theoretical investigation on the sequence selective binding of adriamycin to double-stranded polynucleotides.

Authors:  K S Chen; N Gresh; B Pullman
Journal:  Nucleic Acids Res       Date:  1986-03-11       Impact factor: 16.971

5.  Preclinical evaluation of novel imidazoacridinone derivatives with potent activity against experimental colorectal cancer.

Authors:  A M Burger; J A Double; J Konopa; M C Bibby
Journal:  Br J Cancer       Date:  1996-11       Impact factor: 7.640

6.  Cell-killing activity and kinetic analysis of a novel antitumor compound NC-190, a benzo[a]phenazine derivative.

Authors:  S Nakaike; T Yamagishi; K Nanaumi; S Otomo; S Tsukagoshi
Journal:  Jpn J Cancer Res       Date:  1992-04
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.