Literature DB >> 3480535

Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.

M J Shlomchik1, A H Aucoin, D S Pisetsky, M G Weigert.   

Abstract

Four monoclonal anti-DNA antibodies derived from a single autoimmune MRL/lpr mouse were studied. Three of these antibodies showed similarities in DNA binding; the fourth had a much higher specific activity for single-stranded DNA and, in addition, was unique in binding double-stranded DNA and cardiolipin. Complete nucleotide sequences of heavy- and light-chain variable regions demonstrated that all four antibodies are clonally related. The sequences also showed numerous somatic mutations, the distribution of which suggests that positive selection by antigen operated on these clonally related autoantibodies.

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Year:  1987        PMID： 3480535      PMCID： PMC299710          DOI： 10.1073/pnas.84.24.9150

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  34 in total

1.  Deoxybonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus.

Authors:  E M Tan; P H Schur; R I Carr; H G Kunkel
Journal:  J Clin Invest       Date:  1966-11       Impact factor: 14.808

Review 2.  Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine.

Authors:  E M Tan
Journal:  Adv Immunol       Date:  1982       Impact factor: 3.543

3.  Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

Authors:  F W Alt; D Baltimore
Journal:  Proc Natl Acad Sci U S A       Date:  1982-07       Impact factor: 11.205

4.  Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression.

Authors:  C Coleclough; R P Perry; K Karjalainen; M Weigert
Journal:  Nature       Date:  1981-04-02       Impact factor: 49.962

5.  A high frequency idiotypic marker of anti-DNA autoantibodies in MRL-Ipr/Ipr mice.

Authors:  J Rauch; E Murphy; J B Roths; B D Stollar; R S Schwartz
Journal:  J Immunol       Date:  1982-07       Impact factor: 5.422

6.  Anti-DNA autoantibodies in (NZB X NZW)F1 mice are clonally heterogeneous, but the majority share a common idiotype.

Authors:  T N Marion; A R Lawton; J F Kearney; D E Briles
Journal:  J Immunol       Date:  1982-02       Impact factor: 5.422

7.  Polyspecific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids.

Authors:  E M Lafer; J Rauch; C Andrzejewski; D Mudd; B Furie; B Furie; R S Schwartz; B D Stollar
Journal:  J Exp Med       Date:  1981-04-01       Impact factor: 14.307

8.  Correlation between clinical activity of systemic lupus erythematosus and the amounts of DNA in DNA/anti-DNA antibody immune complexes.

Authors:  C Morimoto; H Sano; T Abe; M Homma; A D Steinberg
Journal:  J Immunol       Date:  1982-11       Impact factor: 5.422

9.  Use of monoclonal antibodies to identify shared idiotypes on human antibodies to native DNA from patients with systemic lupus erythematosus.

Authors:  G Solomon; J Schiffenbauer; H D Keiser; B Diamond
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205

10.  A simple enzyme-linked immunosorbent assay for antibodies to native DNA.

Authors:  D S Pisetsky; D V Peters
Journal:  J Immunol Methods       Date:  1981       Impact factor: 2.303
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  144 in total

1.  Age-related alterations of somatic hypermutation and CDR3 lengths in human Vkappa4-expressing B lymphocytes.

Authors:  D Troutaud; M Drouet; C Decourt; C Le Morvan; M Cogné
Journal:  Immunology       Date:  1999-06       Impact factor: 7.397

Review 2.  Somatic hypermutation in human B cell subsets.

Authors:  N S Longo; P E Lipsky
Journal:  Springer Semin Immunopathol       Date:  2001-12

3.  Donor CD8 T cell activation is critical for greater renal disease severity in female chronic graft-vs.-host mice and is associated with increased splenic ICOS(hi) host CD4 T cells and IL-21 expression.

Authors:  Anthony D Foster; Mark Haas; Irina Puliaeva; Kateryna Soloviova; Roman Puliaev; Charles S Via
Journal:  Clin Immunol       Date:  2010-05-06       Impact factor: 3.969

4.  Analysis of somatic hypermutation and antigenic selection in the clonal B cell in immunoglobulin light chain amyloidosis (AL).

Authors:  Roshini S Abraham; Susan M Geyer; Marina Ramírez-Alvarado; Tammy L Price-Troska; Morie A Gertz; Rafael Fonseca
Journal:  J Clin Immunol       Date:  2004-07       Impact factor: 8.317

5.  B-cell proliferation initiated by Ia cross-linking and sustained by interleukins leads to class switching but not somatic mutation in vitro.

Authors:  L J Wysocki; G Creadon; K R Lehmann; J C Cambier
Journal:  Immunology       Date:  1992-01       Impact factor: 7.397

Review 6.  The role of autoantigens in the induction and maintenance of autoimmunity.

Authors:  P H Plotz
Journal:  Mol Biol Rep       Date:  1992-06       Impact factor: 2.316

Review 7.  Polyreactive antibodies in adaptive immune responses to viruses.

Authors:  Hugo Mouquet; Michel C Nussenzweig
Journal:  Cell Mol Life Sci       Date:  2011-11-02       Impact factor: 9.261

Review 8.  The biochemistry and genetics of DNA and anti-DNA antibodies.

Authors:  B D Stollar
Journal:  Clin Rheumatol       Date:  1990-03       Impact factor: 2.980

Review 9.  Molecular underpinning of B-cell anergy.

Authors:  Yuval Yarkoni; Andrew Getahun; John C Cambier
Journal:  Immunol Rev       Date:  2010-09       Impact factor: 12.988

10.  Two acquired immunodeficiency syndrome-associated Burkitt's lymphomas produce specific anti-i IgM cold agglutinins using somatically mutated VH4-21 segments.

Authors:  P Riboldi; G Gaidano; E W Schettino; T G Steger; D M Knowles; R Dalla-Favera; P Casali
Journal:  Blood       Date:  1994-05-15       Impact factor: 22.113
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