Literature DB >> 348011

The role of prostaglandins in inflammation.

T J Williams.   

Abstract

Our work suggests that aspirin-like drugs suppress inflammatory oedema not by reducing vessel wall permeability but by inhibiting the production of vasodilator mediators (prostaglandins), which results in a reduction in plasma exudation. Thus aspirin-like drugs appear to inhibit inflammatory swelling in the same manner as the traditional method of cooling with an ice-pack--by constricting the dilated blood vessels.

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Year:  1978        PMID： 348011      PMCID： PMC2492079     

Source DB:  PubMed          Journal:  Ann R Coll Surg Engl        ISSN： 0035-8843            Impact factor:   1.891


  11 in total

1.  Prostaglandins, aspirin-like drugs and the oedema of inflammation.

Authors:  S Moncada; S H Ferreira; J R Vane
Journal:  Nature       Date:  1973-11-23       Impact factor: 49.962

2.  Prostaglandins as potentiators of increased vascular permeability in inflammation.

Authors:  T J Williams; J Morley
Journal:  Nature       Date:  1973-11-23       Impact factor: 49.962

3.  Cutaneous vascular reactions to prostaglandins in healthy subjects and in patients with urticaria and atopic dermatitis.

Authors:  L Juhlin; G Michaëlsson
Journal:  Acta Derm Venereol       Date:  1969       Impact factor: 4.437

4.  Role of prostaglandin endoperoxide PGG2 in inflammatory processes.

Authors:  F A Kuehl; J L Humes; R W Egan; E A Ham; G C Beveridge; C G Van Arman
Journal:  Nature       Date:  1977-01-13       Impact factor: 49.962

5.  Prostaglandins, aspirin-like drugs and analgesia.

Authors:  S H Ferreira
Journal:  Nat New Biol       Date:  1972-12-13

6.  Role of prostaglandin-mediated vasodilatation in inflammation.

Authors:  T J Williams; M J Peck
Journal:  Nature       Date:  1977-12-08       Impact factor: 49.962

7.  An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.

Authors:  S Moncada; R Gryglewski; S Bunting; J R Vane
Journal:  Nature       Date:  1976-10-21       Impact factor: 49.962

8.  Prostacyclin (PGI2) potentiates bradykinin-induced plasma exudation in rabbit skin [proceedings].

Authors:  M J Peck; T J Williams; G P Lewis
Journal:  Br J Pharmacol       Date:  1978-03       Impact factor: 8.739

9.  Interaction between prostaglandins E and F given intradermally in the rat.

Authors:  P Crunkhorn; A L Willis
Journal:  Br J Pharmacol       Date:  1971-03       Impact factor: 8.739

10.  Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

Authors:  M Hamberg; J Svensson; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1975-08       Impact factor: 11.205
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  4 in total

1.  Methyl-1-hydroxy-2-naphthoate, a novel naphthol derivative, inhibits lipopolysaccharide-induced inflammatory response in macrophages via suppression of NF-κB, JNK and p38 MAPK pathways.

Authors:  Jun-Yan Zhang; Hong Jin; Guang-Fa Wang; Peng-Jiu Yu; Shao-Yu Wu; Zheng-Guang Zhu; Zhong-Huang Li; Yuan-Xin Tian; Wei Xu; Jia-Jie Zhang; Shu-Guang Wu
Journal:  Inflamm Res       Date:  2011-06-11       Impact factor: 4.575

2.  Some cellular and pathophysiological correlates of the inflammatory effects of a synthetic immunomodulatory agent, muramyl dipeptide (MDP).

Authors:  Z Zídek; D Franková; K Masek
Journal:  Agents Actions       Date:  1993-01

3.  Pattern of pharmacological research from the last six decades.

Authors:  Rupa Joshi; Saniya Mahendiratta; Ajay Prakash; Bikash Medhi
Journal:  Indian J Pharmacol       Date:  2019 Mar-Apr       Impact factor: 1.200

4.  Inflammatory process in Alzheimer's Disease.

Authors:  Marco A Meraz-Ríos; Danira Toral-Rios; Diana Franco-Bocanegra; Juana Villeda-Hernández; Victoria Campos-Peña
Journal:  Front Integr Neurosci       Date:  2013-08-13
  4 in total

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