| Literature DB >> 34800227 |
Lei Wang1, Ruixuan Zheng1, Ying Xu1, Ziyun Zhou1, Ping Guan1, Yanling Wu1, Jian Zhou2, Zaohuo Cheng3, Lili Zhang4.
Abstract
Autism Spectrum Disorder (ASD) is a serious neurodevelopmental disorder with no clinical biomarker. This study used untargeted metabolomic analysis to identify metabolic characteristics in plasma that can distinguish ASD children. 29 boys with ASD (3.02 ± 0.67 years) and 30 typically developing (TD) boys (3.13 ± 0.46 years) were recruited. Developmental and behavioral assessments were conducted in ASD group. Samples of plasma were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The association between metabolite concentration and scale score was assessed by Spearman rank correlation. Altered metabolic characteristics were found in boys with ASD. In Receiver Operating Characteristic (ROC) analysis, ornithine had the highest AUC (Area under ROC) value. Furthermore, the concentration of choline and ornithine was negatively correlated with ABC-language score in ASD group.Entities:
Keywords: Autism Spectrum Disorder (ASD); Liquid chromatography–tandem mass spectrometry (LC–MS/MS); Metabolic profile; Plasma
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Year: 2021 PMID： 34800227 DOI： 10.1007/s10803-021-05364-3
Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257