Wanying Shan1, Liang Xu2, Zhuoyin Qiu1, Jingwen Wang1, Jiaxing Shao1, Jie Feng3, Jie Zhao4. 1. Department of Neurology, Suzhou Ninth People's Hospital, Soochow University, No. 2666 Ludang Road, Suzhou, 215200, Jiangsu, China. 2. Department of Anesthesiology, the First Affiliated Hospital of Soochow University, No.899 Pinghai Road, Suzhou, 215000, Jiangsu, China. 3. Department of Neurology, Suzhou Ninth People's Hospital, Soochow University, No. 2666 Ludang Road, Suzhou, 215200, Jiangsu, China. 1016909765@qq.com. 4. Department of Gerontology, Suzhou Ninth People's Hospital, Soochow University, No. 2666 Ludang Road, Suzhou, 215200, Jiangsu, China. DrZHao_0529@163.com.
Abstract
BACKGROUND AND PURPOSE: Increased high-mobility group box 1 (HMGB1) levels were found in patients after acute ischemic stroke. The aim of this study was to examine whether the circulating HMGB1 levels could predict the 3-month post-stroke depression (PSD). METHODS: The subjects were first-ever ischemic stroke patients who were hospitalized during the period from July 2020 to December 2020. HMGB1 concentrations were measured by enzyme-linked immunosorbent assay after admission. A 24-item Hamilton Depression Rating Scale was performed to evaluate PSD at 3 months after stroke. RESULTS: The analyses included 324 participants (mean age, 63.7 years; 171 male). Ninety-four patients (29.0%) were diagnosed as having PSD at 3 months. The median serum HMGB1 levels at admission was 7.5 ng/mL (IQR, 4.4-11.3 ng/mL). The PSD distribution across the HMGB1 quartiles ranged between 17.5% (first quartile) and 57.5% (fourth quartile). After covariate adjustments, the fourth quartile of HMGB1 was found to be associated with a higher risk of PSD (as compared with first HMGB1 quartile, odd ratio, 1.26; 95% confidence interval [CI], 1.17-1.35; P < 0.001). The area under the receiver operating characteristic curve of HMGB1 was 0.726 (95% CI 0.660-0.792) for PSD. Similar results were found when HMGB1 was analyzed as continuous variable. Furthermore, the optimal cutoff point of circulating HMGB1 levels was 8.6 ng/mL, with a sensitivity of 69.2% and a specificity of 73.9%. CONCLUSIONS: This study demonstrated that higher HMGB1 levels in the acute phase of ischemic stroke were associated with increased risk of PSD.
BACKGROUND AND PURPOSE: Increased high-mobility group box 1 (HMGB1) levels were found in patients after acute ischemic stroke. The aim of this study was to examine whether the circulating HMGB1 levels could predict the 3-month post-stroke depression (PSD). METHODS: The subjects were first-ever ischemic stroke patients who were hospitalized during the period from July 2020 to December 2020. HMGB1 concentrations were measured by enzyme-linked immunosorbent assay after admission. A 24-item Hamilton Depression Rating Scale was performed to evaluate PSD at 3 months after stroke. RESULTS: The analyses included 324 participants (mean age, 63.7 years; 171 male). Ninety-four patients (29.0%) were diagnosed as having PSD at 3 months. The median serum HMGB1 levels at admission was 7.5 ng/mL (IQR, 4.4-11.3 ng/mL). The PSD distribution across the HMGB1 quartiles ranged between 17.5% (first quartile) and 57.5% (fourth quartile). After covariate adjustments, the fourth quartile of HMGB1 was found to be associated with a higher risk of PSD (as compared with first HMGB1 quartile, odd ratio, 1.26; 95% confidence interval [CI], 1.17-1.35; P < 0.001). The area under the receiver operating characteristic curve of HMGB1 was 0.726 (95% CI 0.660-0.792) for PSD. Similar results were found when HMGB1 was analyzed as continuous variable. Furthermore, the optimal cutoff point of circulating HMGB1 levels was 8.6 ng/mL, with a sensitivity of 69.2% and a specificity of 73.9%. CONCLUSIONS: This study demonstrated that higher HMGB1 levels in the acute phase of ischemic stroke were associated with increased risk of PSD.
Authors: X Zhang; Y Tang; Y Xie; C Ding; J Xiao; X Jiang; H Shan; Y Lin; C Li; D Hu; T Li; L Sheng Journal: Eur J Neurol Date: 2016-12-09 Impact factor: 6.089
Authors: Laura K Fonken; Matthew G Frank; Meagan M Kitt; Heather M D'Angelo; Diana M Norden; Michael D Weber; Ruth M Barrientos; Jonathan P Godbout; Linda R Watkins; Steven F Maier Journal: J Neurosci Date: 2016-07-27 Impact factor: 6.167