Nita H Mukand1, Naomi Y Ko2, Nadia A Nabulsi3, Colin C Hubbard3,4, Brian C-H Chiu5, Kent F Hoskins6, Gregory S Calip7. 1. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA. 2. School of Medicine, Section of Hematology Oncology, Boston University, Boston, MA, USA. 3. Center for Pharmacoepidemiology and Pharmacoeconomic Research, University of Illinois at Chicago, 833 South Wood Street MC 871, Chicago, IL, 60612<, USA. 4. Department of Medicine, University of California San Francisco, San Francisco, CA, USA. 5. Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA. 6. Division of Hematology and Oncology, University of Illinois at Chicago, Chicago, IL, USA. 7. Center for Pharmacoepidemiology and Pharmacoeconomic Research, University of Illinois at Chicago, 833 South Wood Street MC 871, Chicago, IL, 60612<, USA. gcalip@uic.edu.
Abstract
BACKGROUND: Physical limitations prior to cancer diagnosis may lead to suboptimal health outcomes. Our objective was to evaluate the impacts of poor physical health-related quality of life (HRQOL) and physical functioning (PF) on the risk of contralateral breast cancer (CBC). METHODS: We performed a nested case-control study of women with invasive unilateral breast cancer (UBC) who did not receive prophylactic contralateral mastectomy using the Surveillance, Epidemiology and End Results Medicare Health Outcomes Survey data resource. Among 2938 women aged ≥ 65 years diagnosed with first stage I-III UBC between 1997 and 2011, we identified 100 subsequent CBC cases and 915 matched controls without CBC using incidence density sampling without replacement. Pre-diagnosis physical HRQOL and PF were determined using Medical Outcomes Trust Short Form-36 (SF-36)/Veterans Rand 12-Item Health Survey (VR-12) responses within 2 years prior to first UBC diagnosis. We estimated adjusted odds ratios (OR) and 95% confidence intervals (CI) using conditional logistic regression models. RESULTS: Cases and controls were similar with respect to comorbidities, stage, surgery, and radiation treatments, but differed by hormone receptor status (ER/PR-negative, 23% and 11%, respectively) of first UBC. Cases had modestly lower mean pre-diagnosis physical HRQOL (- 1.8) and PF (- 2.2) scores. In multivariable models, we observed an increased CBC risk associated with low physical HRQOL (lowest vs. highest quartile, OR = 1.8; 95% CI 0.8-4.3), but CIs included 1.0. Low PF was associated with a 2.7-fold (95% CI 1.1-6.7) increased CBC risk. CONCLUSIONS: Findings indicate that low physical HRQOL, specifically poor PF, is associated with CBC risk. Efforts to understand and minimize declines in PF post-breast cancer are well motivated.
BACKGROUND: Physical limitations prior to cancer diagnosis may lead to suboptimal health outcomes. Our objective was to evaluate the impacts of poor physical health-related quality of life (HRQOL) and physical functioning (PF) on the risk of contralateral breast cancer (CBC). METHODS: We performed a nested case-control study of women with invasive unilateral breast cancer (UBC) who did not receive prophylactic contralateral mastectomy using the Surveillance, Epidemiology and End Results Medicare Health Outcomes Survey data resource. Among 2938 women aged ≥ 65 years diagnosed with first stage I-III UBC between 1997 and 2011, we identified 100 subsequent CBC cases and 915 matched controls without CBC using incidence density sampling without replacement. Pre-diagnosis physical HRQOL and PF were determined using Medical Outcomes Trust Short Form-36 (SF-36)/Veterans Rand 12-Item Health Survey (VR-12) responses within 2 years prior to first UBC diagnosis. We estimated adjusted odds ratios (OR) and 95% confidence intervals (CI) using conditional logistic regression models. RESULTS: Cases and controls were similar with respect to comorbidities, stage, surgery, and radiation treatments, but differed by hormone receptor status (ER/PR-negative, 23% and 11%, respectively) of first UBC. Cases had modestly lower mean pre-diagnosis physical HRQOL (- 1.8) and PF (- 2.2) scores. In multivariable models, we observed an increased CBC risk associated with low physical HRQOL (lowest vs. highest quartile, OR = 1.8; 95% CI 0.8-4.3), but CIs included 1.0. Low PF was associated with a 2.7-fold (95% CI 1.1-6.7) increased CBC risk. CONCLUSIONS: Findings indicate that low physical HRQOL, specifically poor PF, is associated with CBC risk. Efforts to understand and minimize declines in PF post-breast cancer are well motivated.
Authors: Nazmus Saquib; John P Pierce; Juliann Saquib; Shirley W Flatt; Loki Natarajan; Wayne A Bardwell; Ruth E Patterson; Marcia L Stefanick; Cynthia A Thomson; Cheryl L Rock; Lovell A Jones; Ellen B Gold; Njeri Karanja; Barbara A Parker Journal: Psychooncology Date: 2011-03 Impact factor: 3.894
Authors: Kerry S Courneya; Roanne J Segal; Donald C McKenzie; Huiru Dong; Karen Gelmon; Christine M Friedenreich; Yutaka Yasui; Robert D Reid; Jennifer J Crawford; John R Mackey Journal: Med Sci Sports Exerc Date: 2014-09 Impact factor: 5.411
Authors: Delal Akdeniz; Marjanka K Schmidt; Caroline M Seynaeve; Danielle McCool; Daniele Giardiello; Alexandra J van den Broek; Michael Hauptmann; Ewout W Steyerberg; Maartje J Hooning Journal: Breast Date: 2018-12-06 Impact factor: 4.380
Authors: Dejana Braithwaite; William A Satariano; Barbara Sternfeld; Robert A Hiatt; Patricia A Ganz; Karla Kerlikowske; Dan H Moore; Martha L Slattery; Martin Tammemagi; Adrienne Castillo; Michelle Melisko; Laura Esserman; Erin K Weltzien; Bette J Caan Journal: J Natl Cancer Inst Date: 2010-09-22 Impact factor: 13.506
Authors: Lu Chen; Jessica Chubak; Denise M Boudreau; William E Barlow; Noel S Weiss; Christopher I Li Journal: Cancer Res Date: 2017-09-21 Impact factor: 12.701
Authors: Vanessa B Sheppard; Leigh Anne Faul; George Luta; Jonathan D Clapp; Rachel L Yung; Judy Huei-Yu Wang; Gretchen Kimmick; Claudine Isaacs; Michelle Tallarico; William T Barry; Brandelyn N Pitcher; Clifford Hudis; Eric P Winer; Harvey J Cohen; Hyman B Muss; Arti Hurria; Jeanne S Mandelblatt Journal: J Clin Oncol Date: 2014-06-16 Impact factor: 44.544
Authors: Arti Hurria; Enrique Soto-Perez-de-Celis; Jacob B Allred; Harvey Jay Cohen; Anait Arsenyan; Karla Ballman; Jennifer Le-Rademacher; Aminah Jatoi; Julie Filo; Jeanne Mandelblatt; Jacqueline M Lafky; Gretchen Kimmick; Heidi D Klepin; Rachel A Freedman; Harold Burstein; Julie Gralow; Antonio C Wolff; Gustav Magrinat; Myra Barginear; Hyman Muss Journal: J Am Geriatr Soc Date: 2018-08-26 Impact factor: 5.562
Authors: Julia A Knight; Leslie Bernstein; Joan Largent; Marinela Capanu; Colin B Begg; Lene Mellemkjaer; Charles F Lynch; Kathleen E Malone; Anne S Reiner; Xiaolin Liang; Robert W Haile; John D Boice; Jonine L Bernstein Journal: Am J Epidemiol Date: 2009-02-11 Impact factor: 4.897