Literature DB >> 3479411

New antibiotics from genetically engineered actinomycetes. I. 2-Norerythromycins, isolation and structural determinations.

J B McAlpine1, J S Tuan, D P Brown, K D Grebner, D N Whittern, A Buko, L Katz.   

Abstract

Novel macrolide antibiotics have been isolated from a genetically manipulated actinomycete. The major components produced have been isolated and identified as 2-norerythromycins A, B, C and D by mass spectrometry and extensive 1D and 2D NMR experiments.

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Year:  1987        PMID： 3479411     DOI： 10.7164/antibiotics.40.1115

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  9 in total

Review 1.  Analysis of an 8.1-kb DNA fragment contiguous with the erythromycin gene cluster of Saccharopolyspora erythraea in the eryCI-flanking region.

Authors:  Andrew R Reeves; Gerhard Weber; William H Cernota; J Mark Weber
Journal:  Antimicrob Agents Chemother       Date:  2002-12       Impact factor: 5.191

Review 2.  Discovery and development of new antimicrobial agents.

Authors:  T D Gootz
Journal:  Clin Microbiol Rev       Date:  1990-01       Impact factor: 26.132

Review 3.  Recombinant organisms for production of industrial products.

Authors:  Jose-Luis Adrio; Arnold L Demain
Journal:  Bioeng Bugs       Date:  2009-11-02

Review 4.  A comprehensive review of glycosylated bacterial natural products.

Authors:  Sherif I Elshahawi; Khaled A Shaaban; Madan K Kharel; Jon S Thorson
Journal:  Chem Soc Rev       Date:  2015-11-07       Impact factor: 54.564

5.  Mutation and cloning of eryG, the structural gene for erythromycin O-methyltransferase from Saccharopolyspora erythraea, and expression of eryG in Escherichia coli.

Authors:  T J Paulus; J S Tuan; V E Luebke; G T Maine; J P DeWitt; L Katz
Journal:  J Bacteriol       Date:  1990-05       Impact factor: 3.490

6.  Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives.

Authors:  X Ruan; A Pereda; D L Stassi; D Zeidner; R G Summers; M Jackson; A Shivakumar; S Kakavas; M J Staver; S Donadio; L Katz
Journal:  J Bacteriol       Date:  1997-10       Impact factor: 3.490

7.  An erythromycin analog produced by reprogramming of polyketide synthesis.

Authors:  S Donadio; J B McAlpine; P J Sheldon; M Jackson; L Katz
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-01       Impact factor: 11.205

8.  Identification of a Saccharopolyspora erythraea gene required for the final hydroxylation step in erythromycin biosynthesis.

Authors:  D Stassi; S Donadio; M J Staver; L Katz
Journal:  J Bacteriol       Date:  1993-01       Impact factor: 3.490

Review 9.  Expression of polyketide biosynthesis and regulatory genes in heterologous streptomycetes.

Authors:  W R Strohl; P L Bartel; Y Li; N C Connors; R H Woodman
Journal:  J Ind Microbiol       Date:  1991-04
  9 in total

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