Masoud Dadashi1, Fatemeh Sameni2, Nazila Bostanshirin3, Somayeh Yaslianifard3, Nafiseh Khosravi-Dehaghi4, Mohammad Javad Nasiri5, Mehdi Goudarzi5, Ali Hashemi5, Bahareh Hajikhani6. 1. Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran; Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. 2. Department of Microbiology, School of Medicine, Shahed University, Tehran, Iran. 3. Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran. 4. Department of Pharmacognosy, School of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran; Evidence-Based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran. 5. Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 6. Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: b.hajikhani@gmail.com.
Abstract
OBJECTIVES: The continuing rise in infections caused by multidrug-resistant (MDR) bacteria is one of the most serious public-health issues in society today. Colistin is a last-resort antimicrobial drug used to treat infections caused by MDR Gram-negative bacteria, therefore resistance to this antibiotic is extremely hazardous. The current study aimed to evaluate the global prevalence nd distribution of colistin resistance genes among human clinical isolates of Escherichia coli by systematic review. METHODS: PubMed, Embase and Web of Science databases were systematically searched. For further evaluation, all original English language articles that reported colistin resistance in E. coli clinical isolates published between 2000 and 2020 were examined. RESULTS: Of 4857 initial articles, after various stages of review and evaluation 190 related articles were selected for the systematic review. More than 79% of the publications selected in this research were published from 2014-2020. In Asia, Europe, America, Africa and Oceania, the prevalence of mobile colistin resistance (mcr)-harbouring colistin-resistant E. coli was 66.72%, 25.49%, 5.19%, 2.27% and 0.32 %, respectively. CONCLUSION: The recent widespread dissemination of E. coli strains harbouring mcr genes conferring colistin resistance, especially in Asia and Europe, is concerning and requires more attention.
OBJECTIVES: The continuing rise in infections caused by multidrug-resistant (MDR) bacteria is one of the most serious public-health issues in society today. Colistin is a last-resort antimicrobial drug used to treat infections caused by MDR Gram-negative bacteria, therefore resistance to this antibiotic is extremely hazardous. The current study aimed to evaluate the global prevalence nd distribution of colistin resistance genes among human clinical isolates of Escherichia coli by systematic review. METHODS: PubMed, Embase and Web of Science databases were systematically searched. For further evaluation, all original English language articles that reported colistin resistance in E. coli clinical isolates published between 2000 and 2020 were examined. RESULTS: Of 4857 initial articles, after various stages of review and evaluation 190 related articles were selected for the systematic review. More than 79% of the publications selected in this research were published from 2014-2020. In Asia, Europe, America, Africa and Oceania, the prevalence of mobile colistin resistance (mcr)-harbouring colistin-resistant E. coli was 66.72%, 25.49%, 5.19%, 2.27% and 0.32 %, respectively. CONCLUSION: The recent widespread dissemination of E. coli strains harbouring mcr genes conferring colistin resistance, especially in Asia and Europe, is concerning and requires more attention.
Authors: Luciana Sampaio Lima; Aldo Aparecido Proietti-Junior; Yan Corrêa Rodrigues; Marcelo Cleyton da Silva Vieira; Luana Nepomuceno Gondim Costa Lima; Cintya de Oliveira Souza; Verônica Dias Gonçalves; Marcelo de Oliveira Lima; Dália Dos Prazeres Rodrigues; Karla Valéria Batista Lima Journal: Microorganisms Date: 2022-04-13
Authors: José Antonio Magaña-Lizárraga; Bruno Gómez-Gil; José Guadalupe Rendón-Maldonado; Francisco Delgado-Vargas; Inés Fernando Vega-López; María Elena Báez-Flores Journal: Microorganisms Date: 2022-03-20