MXene/carbon nanohorns decorated with conductive molecularly imprinted poly(hydroxymethyl-3,4-ethylenedioxythiophene) for voltammetric detection of adrenaline.

A novel molecularly imprinted sensor was developed for the voltammetric determination of adrenaline (AD). MXene/carbon nanohorn (MXene/CNH) composite with good electric conductivity and enormous accessible active sites was firstly introduced as catalytic substrate. Subsequently, molecularly imprinted polymer (MIP) film was fabricated in mixed solutions containing hydroxymethyl-3,4-ethylenedioxythiophene (functional monomer) and AD (template) through electro-polymerization process. A molecularly imprinted sensor was formed after removing the template. The morphology and elemental composition of the prepared composites were studied by scanning electron microscopy and X-ray photoelectron spectroscopy. Cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS) were used to investigate the electrochemical performance of the molecularly imprinted sensors. Under optimized conditions, the designed sensor displays a wide linear range from 1.0 nM to 60.0 μM and a low limit of detection of 0.3 nM. The developed sensor also presents good selectivity, reproducibility and long-term stability, and satisfactory feasibility in practical sample analysis. MXene/carbon nanohorns decorated with conductive molecularly imprinted poly(hydroxymethyl-3,4-ethylenedioxythiophene) was proposed for highly sensitive and selective detection of adrenaline.