Thomas W Bauer1, Yaxia Zhang2, Madeleine A Gao3, Bin Q Lin4, Matthew F Koff5. 1. Hospital for Special Surgery, Department of Pathology and Laboratory Medicine, 535 East 70th Street, New York, NY, USA. Electronic address: bauert@hss.edu. 2. Hospital for Special Surgery, Department of Pathology and Laboratory Medicine, 535 East 70th Street, New York, NY, USA. Electronic address: zhangya@hss.edu. 3. Hospital for Special Surgery, MRI Research Laboratory, 535 East 70th Street, New York, NY, USA. Electronic address: madeleinegao@gmail.com. 4. Hospital for Special Surgery, MRI Research Laboratory, 535 East 70th Street, New York, NY, USA. Electronic address: bin_lin@alumni.brown.edu. 5. Hospital for Special Surgery, MRI Research Laboratory, 535 East 70th Street, New York, NY, USA. Electronic address: koffm@hss.edu.
Abstract
BACKGROUND: Several previous studies have described broad histologic classifications of peri-prosthetic reactions that likely reflect the underlying mechanism of arthroplasty failure; however, a consensus has not yet been reached about the relative importance of individual observations. QUESTION/ PURPOSE: The purpose of this study was to evaluate the inter-examiner repeatability of commonly used histopathologic grading methods, and to determine the utility of assigning a more simple, global categorization in patients undergoing revision THA surgery of implants with a variety of bearing combinations. METHODS: Between March 2013 and February 2020, a total of 2131 patients underwent revision hip arthroplasty surgery at a one center, of which 12% (248 of 2131) of patients were enrolled. Two pathologists independently reviewed microscope slides of periprosthetic tissue from these patients, of which 425 slides (229 hips, 222 subjects) were reviewed by both pathologists. Separate slides were used for a priori training of the pathologists. Slides were evaluated with the Campbell Aseptic Lymphocyte-dominant Vasculitis-Associated Lesion (ALVAL) score, the Oxford ALVAL score as modified by Grammatopolous, the Fujishiro and Natu scores, and a proposed simplified pattern classification, similar to that of Krenn et al., that incorporates individual factors of these existing scoring methods and was previously shown to correspond to Magnetic Resonance Imaging findings. Inter-rater agreement was assessed using Gwet's AC1 and AC2 coefficients and correspondence analysis was used to examine associations between individual factors of prior scoring methods with the proposed major pattern. RESULTS: Almost perfect inter-rater repeatability (Gwet's AC2 > 0.8) was found for 71% (15/21) of the individual factors, and substantial interrater agreement was found for the proposed major overall pattern (Gwet's AC1: 0.80, 95%CI: 0.72-0.85). Correspondence analysis was able to explain 89-91% of data variability and was able to identify individual features not commonly associated with a major pattern, but discriminatory of the major pattern, such as "Lymph Cuff Thickness 0.25-0.5″ with ALVAL. CONCLUSION: In contrast to prior examinations, excellent interrater agreement was found that may be attributable to a priori training of raters with a test set of slides or difficulty of interpreting grading criteria. The proposed simplified major pattern classification may facilitate evaluation of histopathologic tissue samples.
BACKGROUND: Several previous studies have described broad histologic classifications of peri-prosthetic reactions that likely reflect the underlying mechanism of arthroplasty failure; however, a consensus has not yet been reached about the relative importance of individual observations. QUESTION/ PURPOSE: The purpose of this study was to evaluate the inter-examiner repeatability of commonly used histopathologic grading methods, and to determine the utility of assigning a more simple, global categorization in patients undergoing revision THA surgery of implants with a variety of bearing combinations. METHODS: Between March 2013 and February 2020, a total of 2131 patients underwent revision hip arthroplasty surgery at a one center, of which 12% (248 of 2131) of patients were enrolled. Two pathologists independently reviewed microscope slides of periprosthetic tissue from these patients, of which 425 slides (229 hips, 222 subjects) were reviewed by both pathologists. Separate slides were used for a priori training of the pathologists. Slides were evaluated with the Campbell Aseptic Lymphocyte-dominant Vasculitis-Associated Lesion (ALVAL) score, the Oxford ALVAL score as modified by Grammatopolous, the Fujishiro and Natu scores, and a proposed simplified pattern classification, similar to that of Krenn et al., that incorporates individual factors of these existing scoring methods and was previously shown to correspond to Magnetic Resonance Imaging findings. Inter-rater agreement was assessed using Gwet's AC1 and AC2 coefficients and correspondence analysis was used to examine associations between individual factors of prior scoring methods with the proposed major pattern. RESULTS: Almost perfect inter-rater repeatability (Gwet's AC2 > 0.8) was found for 71% (15/21) of the individual factors, and substantial interrater agreement was found for the proposed major overall pattern (Gwet's AC1: 0.80, 95%CI: 0.72-0.85). Correspondence analysis was able to explain 89-91% of data variability and was able to identify individual features not commonly associated with a major pattern, but discriminatory of the major pattern, such as "Lymph Cuff Thickness 0.25-0.5″ with ALVAL. CONCLUSION: In contrast to prior examinations, excellent interrater agreement was found that may be attributable to a priori training of raters with a test set of slides or difficulty of interpreting grading criteria. The proposed simplified major pattern classification may facilitate evaluation of histopathologic tissue samples.
Authors: George Grammatopoulos; Hemant Pandit; Amir Kamali; Francesca Maggiani; Sion Glyn-Jones; Harinderjit S Gill; David W Murray; Nicholas Athanasou Journal: J Bone Joint Surg Am Date: 2013-06-19 Impact factor: 5.284
Authors: V Krenn; L Morawietz; G Perino; H Kienapfel; R Ascherl; G J Hassenpflug; M Thomsen; P Thomas; M Huber; D Kendoff; D Baumhoer; M G Krukemeyer; S Natu; F Boettner; J Zustin; B Kölbel; W Rüther; J P Kretzer; A Tiemann; A Trampuz; L Frommelt; R Tichilow; S Söder; S Müller; J Parvizi; U Illgner; T Gehrke Journal: Pathol Res Pract Date: 2014-10-17 Impact factor: 3.250
Authors: Hans-Georg Willert; Gottfried H Buchhorn; Afshin Fayyazi; Renata Flury; Markus Windler; Georg Köster; Christoph H Lohmann Journal: J Bone Joint Surg Am Date: 2005-01 Impact factor: 5.284
Authors: Pat Campbell; Edward Ebramzadeh; Scott Nelson; Karren Takamura; Koen De Smet; Harlan C Amstutz Journal: Clin Orthop Relat Res Date: 2010-09 Impact factor: 4.176
Authors: Takaaki Fujishiro; Dirk Jan F Moojen; Naomi Kobayashi; Wouter J A Dhert; Thomas W Bauer Journal: Clin Orthop Relat Res Date: 2010-10-29 Impact factor: 4.176