Literature DB >> 34772619

Life support for transitory exhausted CTLs.

Asmaa Mohamed1, Yina H Huang2.   

Abstract

Di Pilato et al. demonstrate that CXCR6 positions TCF-1- transitory CD8+ cytotoxic lymphocytes (CTLs) with perivascular CCR7+ dendritic cells (DCs) within the tumor stroma to receive IL-15 survival signals. The requirement for CXCR6 and its strong prediction of overall patient survival highlight the importance of continued CTL-DC interactions in sustaining tumor immunity.
Copyright © 2021 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  CXCR6–CXCL16; DC3; IL-15 trans-presentation; perivascular niche; transitory effector T cell; tumor immunity

Mesh：

Year:  2021        PMID： 34772619      PMCID： PMC9107299          DOI： 10.1016/j.it.2021.10.012

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   19.709


  8 in total

1.  Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species.

Authors:  Rapolas Zilionis; Camilla Engblom; Christina Pfirschke; Virginia Savova; David Zemmour; Hatice D Saatcioglu; Indira Krishnan; Giorgia Maroni; Claire V Meyerovitz; Clara M Kerwin; Sun Choi; William G Richards; Assunta De Rienzo; Daniel G Tenen; Raphael Bueno; Elena Levantini; Mikael J Pittet; Allon M Klein
Journal:  Immunity       Date:  2019-04-09       Impact factor: 31.745

2.  Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade.

Authors:  Brian C Miller; Debattama R Sen; Rose Al Abosy; Kevin Bi; Yamini V Virkud; Martin W LaFleur; Kathleen B Yates; Ana Lako; Kristen Felt; Girish S Naik; Michael Manos; Evisa Gjini; Juhi R Kuchroo; Jeffrey J Ishizuka; Jenna L Collier; Gabriel K Griffin; Seth Maleri; Dawn E Comstock; Sarah A Weiss; Flavian D Brown; Arpit Panda; Margaret D Zimmer; Robert T Manguso; F Stephen Hodi; Scott J Rodig; Arlene H Sharpe; W Nicholas Haining
Journal:  Nat Immunol       Date:  2019-02-18       Impact factor: 25.606

3.  Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy.

Authors:  Imran Siddiqui; Karin Schaeuble; Vijaykumar Chennupati; Silvia A Fuertes Marraco; Sandra Calderon-Copete; Daniela Pais Ferreira; Santiago J Carmona; Leonardo Scarpellino; David Gfeller; Sylvain Pradervand; Sanjiv A Luther; Daniel E Speiser; Werner Held
Journal:  Immunity       Date:  2019-01-08       Impact factor: 31.745

4.  Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy.

Authors:  Melvyn T Chow; Aleksandra J Ozga; Rachel L Servis; Dennie T Frederick; Jennifer A Lo; David E Fisher; Gordon J Freeman; Genevieve M Boland; Andrew D Luster
Journal:  Immunity       Date:  2019-05-13       Impact factor: 31.745

5.  Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12.

Authors:  Christopher S Garris; Sean P Arlauckas; Rainer H Kohler; Marcel P Trefny; Seth Garren; Cécile Piot; Camilla Engblom; Christina Pfirschke; Marie Siwicki; Jeremy Gungabeesoon; Gordon J Freeman; Sarah E Warren; SuFey Ong; Erica Browning; Christopher G Twitty; Robert H Pierce; Mai H Le; Alain P Algazi; Adil I Daud; Sara I Pai; Alfred Zippelius; Ralph Weissleder; Mikael J Pittet
Journal:  Immunity       Date:  2018-12-11       Impact factor: 43.474

6.  CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment.

Authors:  Mauro Di Pilato; Raphael Kfuri-Rubens; Jasper N Pruessmann; Aleksandra J Ozga; Marius Messemaker; Bruno L Cadilha; Ramya Sivakumar; Chiara Cianciaruso; Ross D Warner; Francesco Marangoni; Esteban Carrizosa; Stefanie Lesch; James Billingsley; Daniel Perez-Ramos; Fidel Zavala; Esther Rheinbay; Andrew D Luster; Michael Y Gerner; Sebastian Kobold; Mikael J Pittet; Thorsten R Mempel
Journal:  Cell       Date:  2021-08-02       Impact factor: 66.850

7.  ACKR4 restrains antitumor immunity by regulating CCL21.

Authors:  Carly E Whyte; Maleika Osman; Ervin E Kara; Caitlin Abbott; Jade Foeng; Duncan R McKenzie; Kevin A Fenix; Yuka Harata-Lee; Kerrie L Foyle; Sarah T Boyle; Marina Kochetkova; Amelia Roman Aguilera; Jiajie Hou; Xian-Yang Li; Mark A Armstrong; Stephen M Pederson; Iain Comerford; Mark J Smyth; Shaun R McColl
Journal:  J Exp Med       Date:  2020-06-01       Impact factor: 14.307

8.  Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cells.

Authors:  Jennifer L Vella; Aleksey Molodtsov; Christina V Angeles; Bruce R Branchini; Mary Jo Turk; Yina H Huang
Journal:  Life Sci Alliance       Date:  2021-08-06
  8 in total

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