Literature DB >> 3476488

Complete amino acid sequence of human transforming growth factor type beta 2.

H Marquardt, M N Lioubin, T Ikeda.   

Abstract

The complete amino acid sequence of human type beta 2 transforming growth factor (hTGF-beta 2) was determined by automated Edman degradation of S-pyridylethylated hTGF-beta 2 and selected fragments. Cleavage of hTGF-beta 2 by enzymatic and chemical techniques established all the fragments in an unambiguous sequence. Human TGF-beta 2 consists of two disulfide-linked, identical subunits. Each hTGF-beta 2 subunit is a single-chain polypeptide of 112 residues, with a calculated molecular weight of 12,720. Human TGF-beta 2 displays 71.4% sequence homology with the functionally related human TGF-beta 1, and is distantly related (23-40% amino acid identity) to porcine inhibins and activins, the carboxyl-terminal regions of human Müllerian inhibiting substance, and the putative decapentaplegic gene complex protein of Drosophila.

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Year:  1987        PMID： 3476488

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  23 in total

1.  Transforming growth factor-ßs as modulators of pericellular proteolytic events.

Authors:  J Keski-Oja; J Lohi; M Laiho
Journal:  Cytotechnology       Date:  1989-12       Impact factor: 2.058

Review 2.  The Discovery and Early Days of TGF-β: A Historical Perspective.

Authors:  Harold L Moses; Anita B Roberts; Rik Derynck
Journal:  Cold Spring Harb Perspect Biol       Date:  2016-07-01       Impact factor: 10.005

3.  Molecular events in the processing of recombinant type 1 pre-pro-transforming growth factor beta to the mature polypeptide.

Authors:  L E Gentry; M N Lioubin; A F Purchio; H Marquardt
Journal:  Mol Cell Biol       Date:  1988-10       Impact factor: 4.272

4.  Transforming growth factor beta inhibits bone resorption in fetal rat long bone cultures.

Authors:  J Pfeilschifter; S M Seyedin; G R Mundy
Journal:  J Clin Invest       Date:  1988-08       Impact factor: 14.808

5.  Amino acid sequence of the BSC-1 cell growth inhibitor (polyergin) deduced from the nucleotide sequence of the cDNA.

Authors:  S K Hanks; R Armour; J H Baldwin; F Maldonado; J Spiess; R W Holley
Journal:  Proc Natl Acad Sci U S A       Date:  1988-01       Impact factor: 11.205

6.  Osteoblastic and osteoclastic metastases in a single vertebra-a rare presentation.

Authors:  Gian Chand; Ajay Chhabra; Deepshikha Mangat; Suparna Grover
Journal:  J Clin Diagn Res       Date:  2015-02-01

7.  Vascular cells respond differentially to transforming growth factors beta 1 and beta 2 in vitro.

Authors:  J R Merwin; W Newman; L D Beall; A Tucker; J Madri
Journal:  Am J Pathol       Date:  1991-01       Impact factor: 4.307

Review 8.  Bone metabolism and new targets for intervention.

Authors:  Bulent Akduman; E David Crawford
Journal:  Curr Urol Rep       Date:  2007-05       Impact factor: 3.092

9.  Potentiation of transforming growth factor (TGF-beta 1) by natural coral and fibrin in a rabbit cranioplasty model.

Authors:  E Arnaud; C Morieux; M Wybier; M C de Vernejoul
Journal:  Calcif Tissue Int       Date:  1994-06       Impact factor: 4.333

10.  Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat.

Authors:  W E Russell; R J Coffey; A J Ouellette; H L Moses
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205
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