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Literature DB >> 3475713

Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase.

C R Lin, M S Kapiloff, S Durgerian, K Tatemoto, A F Russo, P Hanson, H Schulman, M G Rosenfeld.

Abstract

A calcium/calmodulin-dependent protein kinase type II (CaM-K) alpha-subunit cDNA has been cloned from rat brain. This enzyme is encoded by a 5.1-kilobase mRNA expressed exclusively in the brain. Hybridization histochemistry reveals that the CaM-K mRNA expression corresponds to the distribution of the immunoreactive alpha-subunit protein, suggesting that the high enzyme levels in specific brain areas reflect regional differences in gene expression. The sequence of CaM-K alpha-subunit cDNA indicates a 478-amino acid (54-kDa) protein with three functional domains. The domain organization suggests a structural model for calcium/calmodulin-dependent and independent states that might subserve short- and long-term responses to transient stimuli.

Entities: Gene Species

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Year: 1987 PMID： 3475713 PMCID： PMC298983 DOI： 10.1073/pnas.84.16.5962

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

35 in total

Review 1. Molecular mechanisms for memory: second-messenger induced modifications of protein kinases in nerve cells.

Authors: J H Schwartz; S M Greenberg
Journal: Annu Rev Neurosci Date: 1987 Impact factor: 12.449

2. Ca2+/calmodulin-dependent protein kinase II. Isozymic forms from rat forebrain and cerebellum.

Authors: T L McGuinness; Y Lai; P Greengard
Journal: J Biol Chem Date: 1985-02-10 Impact factor: 5.157

3. Guanosine cyclic 3',5'-phosphate dependent protein kinase, a chimeric protein homologous with two separate protein families.

Authors: K Takio; R D Wade; S B Smith; E G Krebs; K A Walsh; K Titani
Journal: Biochemistry Date: 1984-08-28 Impact factor: 3.162

4. Homology of the gamma subunit of phosphorylase b kinase with cAMP-dependent protein kinase.

Authors: E M Reimann; K Titani; L H Ericsson; R D Wade; E H Fischer; K A Walsh
Journal: Biochemistry Date: 1984-08-28 Impact factor: 3.162

5. Evidence that the major postsynaptic density protein is a component of a Ca2+/calmodulin-dependent protein kinase.

Authors: P T Kelly; T L McGuinness; P Greengard
Journal: Proc Natl Acad Sci U S A Date: 1984-02 Impact factor: 11.205

6. Immunocytochemical localization of calcium/calmodulin-dependent protein kinase II in rat brain.

Authors: C C Ouimet; T L McGuinness; P Greengard
Journal: Proc Natl Acad Sci U S A Date: 1984-09 Impact factor: 11.205

7. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.

Authors: A Ullrich; L Coussens; J S Hayflick; T J Dull; A Gray; A W Tam; J Lee; Y Yarden; T A Libermann; J Schlessinger
Journal: Nature Date: 1984 May 31-Jun 6 Impact factor: 49.962

8. Purification and characterization of a Ca2+/calmodulin-dependent protein kinase from rat brain.

Authors: J Kuret; H Schulman
Journal: Biochemistry Date: 1984-11-06 Impact factor: 3.162

9. Phosphorylation-dependent subcellular translocation of a Ca2+/calmodulin-dependent protein kinase produces an autonomous enzyme in Aplysia neurons.

Authors: T Saitoh; J H Schwartz
Journal: J Cell Biol Date: 1985-03 Impact factor: 10.539

10. Phosphorylation of microtubule-associated proteins by a Ca2+/calmodulin-dependent protein kinase.

Authors: H Schulman
Journal: J Cell Biol Date: 1984-07 Impact factor: 10.539

79 in total

1. Molecular cloning and analysis of Ca2+/calmodulin-dependent protein kinase II from the chicken brain.

Authors: G Li; N Liu; O L Liu; G D Mower; R G Gregg; N G Cooper
Journal: J Mol Neurosci Date: 1998-10 Impact factor: 3.444

Review 2. Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II.

Authors: Andy Hudmon; Howard Schulman
Journal: Biochem J Date: 2002-06-15 Impact factor: 3.857

3. Differential functional properties of calmodulin-dependent protein kinase IIgamma variants isolated from smooth muscle.

Authors: Samudra S Gangopadhyay; Amy L Barber; Cynthia Gallant; Zenon Grabarek; Janet L Smith; Kathleen G Morgan
Journal: Biochem J Date: 2003-06-01 Impact factor: 3.857

4. Regulation of intrasteric inhibition of the multifunctional calcium/calmodulin-dependent protein kinase.

Authors: F H Cruzalegui; M S Kapiloff; J P Morfin; B E Kemp; M G Rosenfeld; A R Means
Journal: Proc Natl Acad Sci U S A Date: 1992-12-15 Impact factor: 11.205

5. Chromosomal localization of the murine genes for the alpha- and beta-subunits of calcium/calmodulin-dependent protein kinase II.

Authors: M Danciger; C A Kozak; M C Adamson; D B Farber
Journal: Mamm Genome Date: 1992 Impact factor: 2.957

6. On the identity of the major postsynaptic density protein.

Authors: K Wu; Y Huang; J Adler; I B Black
Journal: Proc Natl Acad Sci U S A Date: 1992-04-01 Impact factor: 11.205

7. Genetic and molecular analysis of cdr1/nim1 in Schizosaccharomyces pombe.

Authors: H Feilotter; P Nurse; P G Young
Journal: Genetics Date: 1991-02 Impact factor: 4.562

8. Neonatal isolation accelerates the developmental switch in the signalling cascades for long-term potentiation induction.

Authors: Chiung-Chun Huang; Pei-Hsuan Chou; Chih-Hao Yang; Kuei-Sen Hsu
Journal: J Physiol Date: 2005-10-13 Impact factor: 5.182

Review 9. Calmodulin-dependent protein kinase II. Multifunctional roles in neuronal differentiation and synaptic plasticity.

Authors: P T Kelly
Journal: Mol Neurobiol Date: 1991 Impact factor: 5.590

10. Molecular and biochemical characterization of a calcium/calmodulin-binding protein kinase from rice.

Authors: Lei Zhang; Bi-Feng Liu; Shuping Liang; Russell L Jones; Ying-Tang Lu
Journal: Biochem J Date: 2002-11-15 Impact factor: 3.857