Literature DB >> 34739962

Experiment, theory, and simulation of a flow-electrical-split flow thin particle separation device.

Kevin Petersen1, Farhad Shiri2, Tonguc Onur Tasci3, Himanshu Sant2, Joshua Hood4, Bruce Gale2.   

Abstract

Herein, we describe the simulation of a novel flow-electrical-split flow thin (Fl-El-SPLITT) separation device and validate it using existing theory and experimentation for the first time using polystyrene particles of 28 and 1000 nm diameters. The fraction of particles exiting selected ports with DC El-SPLITT is predicted with existing theory, but the theory does not include AC fields, nor does it incorporate the use of crossflows. Using DC fields the El-SPLITT simulation and theory calculated transition points result in the same values. These calculated values accurately predict the experimentally obtained transition point using a 50:50 outlet splitting plane (OSP). Relative to actual experimentally obtained transition points, the calculated values lag behind for a 90:10 OSP, and lead ahead for a 10:90 OSP. The simulation explains trends seen in AC testing, and reasonably predicts the fraction of particles exiting each port. As DC current increases, the amount of AC current required to scatter the particles away from the DC-intended port decreases. The simulation also models a crossflow in a SPLITT system with a DC current applied in a direction opposite the crossflow with some success. Long term steady-state testing without crossflows shows a DC voltage dependent loss of particles. At 8 V DC, total recovery of 28 and 1000 nm particles was 70% and 26%, respectively. This work effectively models a new Fl-El-SPLITT system via Matlab simulation by demonstrating key experimental results such as the influence of DC, AC, and crossflows on the SPLITT separation of polystyrene particles.
Copyright © 2021. Published by Elsevier B.V.

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Mesh:

Year:  2021        PMID: 34739962      PMCID: PMC8791626          DOI: 10.1016/j.chroma.2021.462634

Source DB:  PubMed          Journal:  J Chromatogr A        ISSN: 0021-9673            Impact factor:   4.759


  6 in total

1.  A microfabricated electrical SPLITT system.

Authors:  Nithin Narayanan; Avinash Saldanha; Bruce K Gale
Journal:  Lab Chip       Date:  2005-12-05       Impact factor: 6.799

2.  Improved theory of cyclical electrical field flow fractionation.

Authors:  Ameya Kantak; Srinivas Merugu; Bruce K Gale
Journal:  Electrophoresis       Date:  2006-07       Impact factor: 3.535

3.  Development and Testing of a Continuous Flow-Electrical-Split-Flow Lateral Transport Thin Separation System (Fl-El-SPLITT).

Authors:  Farhad Shiri; Bruce K Gale; Himanshu Sant; Brody King; Gina T Bardi; Joshua L Hood; Kevin E Petersen
Journal:  Anal Chem       Date:  2021-01-21       Impact factor: 6.986

4.  Circuit modification in electrical field flow fractionation systems generating higher resolution separation of nanoparticles.

Authors:  Tonguc O Tasci; William P Johnson; Diego P Fernandez; Eliana Manangon; Bruce K Gale
Journal:  J Chromatogr A       Date:  2014-09-08       Impact factor: 4.759

5.  Properties of an asymmetrical flow field-flow fractionation channel having one permeable wall.

Authors:  K G Wahlund; J C Giddings
Journal:  Anal Chem       Date:  1987-05-01       Impact factor: 6.986

6.  Electrical field-flow fractionation in particle separation. 1. Monodisperse standards.

Authors:  K D Caldwell; Y S Gao
Journal:  Anal Chem       Date:  1993-07-01       Impact factor: 6.986

  6 in total

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