Haiyang Bian1,2, Lidia Mínguez-Alarcón3, Albert Salas-Huetos1, David Bauer4, Paige L Williams5,6, Irene Souter7, Jill Attaman7, Jorge E Chavarro1,5,8. 1. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 2. Institute of Reproductive and Child Health and Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing, China. 3. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 4. Harvard Extension School, Cambridge, MA, USA. 5. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 6. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 7. Vincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, MA. 8. Channing Division of Network Medicine, Harvard Medical School & Brigham and Women's Hospital, Boston, MA, USA.
Abstract
BACKGROUND: Male obesity has been related to poor semen quality and may also have a negative effect on assisted reproductive technologies (ART) outcomes. Whether male waist circumference (WC), as a measure of central obesity, impacts a couple's fertility independently of BMI is unclear. OBJECTIVES: To examine the associations of male WC with semen quality and couples' outcomes of infertility treatment with ART. METHODS: Couples presenting to the Massachusetts General Hospital Fertility Center were invited to participate in the study. Between 2009 and 2019, 269 males provided 671 semen samples and 176 couples underwent 317 ART cycles. Height, weight, and WC were measured on site. We analyzed the association of male WC with semen quality and pregnancy outcomes using cluster-weighted regression models to account for repeated observations while adjusting for potential confounders. Models were also stratified by male BMI (<25 kg/m2 compared with ≥25 kg/m2). RESULTS: The median male age, WC, and BMI were 36.1 years, 96.0 cm, and 26.8 kg/m2, respectively. A 5-cm increase in WC was associated with a 6.3% (95% CI, 2.1-10.5%) lower sperm concentration after adjustment for potential confounders, including BMI. Male WC was also inversely related to the probability of achieving a live birth. For each 5-cm increase in male WC, the odds of a live birth per initiated cycle decreased by 9.0% (95% CI, 1.1%-16.4%) after accounting for several anthropometric and demographic characteristics of both partners. These associations were stronger among males in the normal BMI category (<25 kg/m2) than among overweight or obese males. CONCLUSIONS: A higher male WC may be an additional risk factor for poor outcomes of infertility treatment, even after accounting for male and female partner BMIs, particularly in couples where the male partner has a normal BMI.
BACKGROUND: Male obesity has been related to poor semen quality and may also have a negative effect on assisted reproductive technologies (ART) outcomes. Whether male waist circumference (WC), as a measure of central obesity, impacts a couple's fertility independently of BMI is unclear. OBJECTIVES: To examine the associations of male WC with semen quality and couples' outcomes of infertility treatment with ART. METHODS: Couples presenting to the Massachusetts General Hospital Fertility Center were invited to participate in the study. Between 2009 and 2019, 269 males provided 671 semen samples and 176 couples underwent 317 ART cycles. Height, weight, and WC were measured on site. We analyzed the association of male WC with semen quality and pregnancy outcomes using cluster-weighted regression models to account for repeated observations while adjusting for potential confounders. Models were also stratified by male BMI (<25 kg/m2 compared with ≥25 kg/m2). RESULTS: The median male age, WC, and BMI were 36.1 years, 96.0 cm, and 26.8 kg/m2, respectively. A 5-cm increase in WC was associated with a 6.3% (95% CI, 2.1-10.5%) lower sperm concentration after adjustment for potential confounders, including BMI. Male WC was also inversely related to the probability of achieving a live birth. For each 5-cm increase in male WC, the odds of a live birth per initiated cycle decreased by 9.0% (95% CI, 1.1%-16.4%) after accounting for several anthropometric and demographic characteristics of both partners. These associations were stronger among males in the normal BMI category (<25 kg/m2) than among overweight or obese males. CONCLUSIONS: A higher male WC may be an additional risk factor for poor outcomes of infertility treatment, even after accounting for male and female partner BMIs, particularly in couples where the male partner has a normal BMI.
Authors: Jennifer Yland; Carmen Messerlian; Lidia Mínguez-Alarcón; Jennifer B Ford; Russ Hauser; Paige L Williams Journal: Hum Reprod Date: 2019-03-01 Impact factor: 6.918
Authors: A L Harris; J C Vanegas; E Hariton; P Bortoletto; M Palmor; L A Humphries; C Tanrikut; J E Chavarro; A K Styer Journal: J Assist Reprod Genet Date: 2018-11-10 Impact factor: 3.412
Authors: Albert Salas-Huetos; Leila Maghsoumi-Norouzabad; Emma R James; Douglas T Carrell; Kenneth I Aston; Timothy G Jenkins; Nerea Becerra-Tomás; Ahmad Zare Javid; Reza Abed; Pedro Javier Torres; Eugenia Mercedes Luque; Nicolás David Ramírez; Ana Carolina Martini; Jordi Salas-Salvadó Journal: Obes Rev Date: 2020-07-23 Impact factor: 9.213
Authors: Ian J Neeland; Robert Ross; Jean-Pierre Després; Yuji Matsuzawa; Shizuya Yamashita; Iris Shai; Jaap Seidell; Paolo Magni; Raul D Santos; Benoit Arsenault; Ada Cuevas; Frank B Hu; Bruce Griffin; Alberto Zambon; Philip Barter; Jean-Charles Fruchart; Robert H Eckel Journal: Lancet Diabetes Endocrinol Date: 2019-07-10 Impact factor: 32.069
Authors: A M Wolf; D J Hunter; G A Colditz; J E Manson; M J Stampfer; K A Corsano; B Rosner; A Kriska; W C Willett Journal: Int J Epidemiol Date: 1994-10 Impact factor: 7.196
Authors: Carmen Messerlian; Paige L Williams; Jennifer B Ford; Jorge E Chavarro; Lidia Mínguez-Alarcón; Ramace Dadd; Joseph M Braun; Audrey J Gaskins; John D Meeker; Tamarra James-Todd; Yu-Han Chiu; Feiby L Nassan; Irene Souter; John Petrozza; Myra Keller; Thomas L Toth; Antonia M Calafat; Russ Hauser Journal: Hum Reprod Open Date: 2018-02-20