Literature DB >> 34730970

Divergent, C-C Bond Forming Macrocyclizations Using Modular Sulfonylhydrazone and Derived Substrates.

Wenqing Xu1, Lauren E Brown1, John A Porco1.   

Abstract

A divergent approach to C-C bond forming macrocycle construction is described. Modular sulfonylhydrazone and derived pyridotriazole substrates with three key building blocks have been constructed and cyclized to afford diverse macrocyclic frameworks. Broad substrate scope and functional group tolerance have been demonstrated. In addition, site-selective postfunctionalization allowed for further diversification of macrocyclic cores.

Entities:  

Year:  2021        PMID： 34730970      PMCID： PMC8783553          DOI： 10.1021/acs.joc.1c01848

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  34 in total

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Journal:  J Am Chem Soc       Date:  2021-04-27       Impact factor: 15.419

6.  Catalytic coupling of arene C-H bonds and alkynes for the synthesis of coumarins: substrate scope and application to the development of neuroimaging agents.

Authors:  Paul A Vadola; Dalibor Sames
Journal:  J Org Chem       Date:  2012-07-06       Impact factor: 4.354

7.  Synthesis and inverse electron demand Diels-Alder reactions of 3,6-bis(3,4-dimethoxybenzoyl)-1,2,4,5-tetrazine.

Authors:  Danielle R Soenen; Jeffrey M Zimpleman; Dale L Boger
Journal:  J Org Chem       Date:  2003-05-02       Impact factor: 4.354

8.  Diverse organo-peptide macrocycles via a fast and catalyst-free oxime/intein-mediated dual ligation.

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9.  Rapid generation of macrocycles with natural-product-like side chains by multiple multicomponent macrocyclizations (MiBs).

Authors:  Daniel G Rivera; Otilie E Vercillo; Ludger A Wessjohann
Journal:  Org Biomol Chem       Date:  2008-03-28       Impact factor: 3.876

10.  Copper-diamine-catalyzed N-arylation of pyrroles, pyrazoles, indazoles, imidazoles, and triazoles.

Authors:  Jon C Antilla; Jeremy M Baskin; Timothy E Barder; Stephen L Buchwald
Journal:  J Org Chem       Date:  2004-08-20       Impact factor: 4.354
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