Blayne A Sarazin1, Claire L Ihle2, Philip Owens2,3, Maureen E Lynch4,5. 1. Department of Mechanical Engineering, University of Colorado, 427 UCB, Boulder, CO, 80309, USA. 2. Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA. 3. Department of Veterans Affairs, Research Service, Eastern Colorado Health Care System, Aurora, CO, 80045, USA. 4. Department of Mechanical Engineering, University of Colorado, 427 UCB, Boulder, CO, 80309, USA. Maureen.Lynch@colorado.edu. 5. Biofrontiers Institute, University of Colorado, Boulder, CO, 80309, USA. Maureen.Lynch@colorado.edu.
Abstract
PURPOSE OF REVIEW: In this review, we provide an overview of what is currently known about the impacts of mechanical stimuli on metastatic tumor-induced bone disease (TIBD). Further, we focus on the role of the osteocyte, the skeleton's primary mechanosensory cell, which is central to the skeleton's mechanoresponse, sensing and integrating local mechanical stimuli, and then controlling the downstream remodeling balance as appropriate. RECENT FINDINGS: Exercise and controlled mechanical loading have anabolic effects on bone tissue in models of bone metastasis. They also have anti-tumorigenic properties, in part due to offsetting the vicious cycle of osteolytic bone loss as well as regulating inflammatory signals. The impacts of metastatic cancer on the mechanosensory function of osteocytes remains unclear. Increased mechanical stimuli are a potential method for mitigating TIBD.
PURPOSE OF REVIEW: In this review, we provide an overview of what is currently known about the impacts of mechanical stimuli on metastatic tumor-induced bone disease (TIBD). Further, we focus on the role of the osteocyte, the skeleton's primary mechanosensory cell, which is central to the skeleton's mechanoresponse, sensing and integrating local mechanical stimuli, and then controlling the downstream remodeling balance as appropriate. RECENT FINDINGS: Exercise and controlled mechanical loading have anabolic effects on bone tissue in models of bone metastasis. They also have anti-tumorigenic properties, in part due to offsetting the vicious cycle of osteolytic bone loss as well as regulating inflammatory signals. The impacts of metastatic cancer on the mechanosensory function of osteocytes remains unclear. Increased mechanical stimuli are a potential method for mitigating TIBD.
Authors: Michal Wilk; Jaroslaw Kepski; Justyna Kepska; Stephen Casselli; Sebastian Szmit Journal: BMJ Support Palliat Care Date: 2020-09-17 Impact factor: 3.568
Authors: Fred Saad; Donald M Gleason; Robin Murray; Simon Tchekmedyian; Peter Venner; Louis Lacombe; Joseph L Chin; Jeferson J Vinholes; J Allen Goas; Ming Zheng Journal: J Natl Cancer Inst Date: 2004-06-02 Impact factor: 13.506