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Literature DB >> 34728144

'(m⁶)A' stands for 'autoimmunity': reading, writing, and erasing RNA modifications during inflammation.

Abstract

Covalent RNA modifications that regulate gene expression post transcriptionally, in particular N6-methyladenosine (m6A), are emerging as important regulators of autoimmune responses. Here, we highlight new findings describing the functional diversity and specificity of m6A modifications and their regulation in the context of autoimmunity.

Entities: Chemical

Mesh：

Substances：
RNA, Messenger

Year: 2021 PMID： 34728144 PMCID： PMC9393025 DOI： 10.1016/j.it.2021.10.002

Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 19.709

17 in total

1. The RNA helicase DDX46 inhibits innate immunity by entrapping m⁶A-demethylated antiviral transcripts in the nucleus.

Authors: Qingliang Zheng; Jin Hou; Ye Zhou; Zhenyang Li; Xuetao Cao
Journal: Nat Immunol Date: 2017-08-28 Impact factor: 25.606

2. m⁶A mRNA methylation sustains Treg suppressive functions.

Authors: Jiyu Tong; Guangchao Cao; Ting Zhang; Esen Sefik; Maria Carolina Amezcua Vesely; James P Broughton; Shu Zhu; Huabin Li; Bin Li; Lei Chen; Howard Y Chang; Bing Su; Richard A Flavell; Hua-Bing Li
Journal: Cell Res Date: 2018-01-05 Impact factor: 25.617

3. m⁶A modification controls the innate immune response to infection by targeting type I interferons.

Authors: Roni Winkler; Ella Gillis; Lior Lasman; Modi Safra; Shay Geula; Clara Soyris; Aharon Nachshon; Julie Tai-Schmiedel; Nehemya Friedman; Vu Thuy Khanh Le-Trilling; Mirko Trilling; Michal Mandelboim; Jacob H Hanna; Schraga Schwartz; Noam Stern-Ginossar
Journal: Nat Immunol Date: 2018-12-17 Impact factor: 25.606

Review 4. Regulation of Viral Infection by the RNA Modification N6-Methyladenosine.

Authors: Graham D Williams; Nandan S Gokhale; Stacy M Horner
Journal: Annu Rev Virol Date: 2019-07-05 Impact factor: 10.431

5. Deficient SOCS3 and SHP-1 expression in psoriatic T cells.

Authors: Karsten W Eriksen; Anders Woetmann; Lone Skov; Thorbjørn Krejsgaard; Lone F Bovin; Mikkel L Hansen; Kirsten Grønbaek; Nils Billestrup; Mogens H Nissen; Carsten Geisler; Mariusz A Wasik; Niels Ødum
Journal: J Invest Dermatol Date: 2010-02-04 Impact factor: 8.551

6. The germinal center reaction depends on RNA methylation and divergent functions of specific methyl readers.

Authors: Amalie C Grenov; Lihee Moss; Sarit Edelheit; Ross Cordiner; Dominik Schmiedel; Adi Biram; Jacob H Hanna; Torben Heick Jensen; Schraga Schwartz; Ziv Shulman
Journal: J Exp Med Date: 2021-08-17 Impact factor: 14.307

7. A New Model of Spontaneous Colitis in Mice Induced by Deletion of an RNA m⁶A Methyltransferase Component METTL14 in T Cells.

Authors: Thomas X Lu; Zhong Zheng; Linda Zhang; Hui-Lung Sun; Marc Bissonnette; Haochu Huang; Chuan He
Journal: Cell Mol Gastroenterol Hepatol Date: 2020-07-04

8. METTL3-dependent m⁶A modification programs T follicular helper cell differentiation.

Authors: Yingpeng Yao; Ying Yang; Wenhui Guo; Lifan Xu; Menghao You; Yi-Chang Zhang; Zhen Sun; Xiao Cui; Guotao Yu; Zhihong Qi; Jingjing Liu; Fang Wang; Juanjuan Liu; Tianyan Zhao; Lilin Ye; Yun-Gui Yang; Shuyang Yu
Journal: Nat Commun Date: 2021-02-26 Impact factor: 14.919

9. The m⁶A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis.

Authors: Rami Bechara; Nilesh Amatya; Rachel D Bailey; Yang Li; Felix E Y Aggor; De-Dong Li; Chetan V Jawale; Bianca M Coleman; Ning Dai; Nandan S Gokhale; Tiffany C Taylor; Stacy M Horner; Amanda C Poholek; Anita Bansal; Partha S Biswas; Sarah L Gaffen
Journal: Sci Immunol Date: 2021-07-02