| Literature DB >> 34725508 |
Sydney S Cash1, Alik S Widge2,3, Ishita Basu4, Ali Yousefi4,5, Britni Crocker1, Rina Zelmann1, Angelique C Paulk1, Noam Peled6, Kristen K Ellard4, Daniel S Weisholtz7, G Rees Cosgrove8, Thilo Deckersbach4, Uri T Eden9, Emad N Eskandar10,11, Darin D Dougherty4.
Abstract
Deficits in cognitive control-that is, in the ability to withhold a default pre-potent response in favour of a more adaptive choice-are common in depression, anxiety, addiction and other mental disorders. Here we report proof-of-concept evidence that, in participants undergoing intracranial epilepsy monitoring, closed-loop direct stimulation of the internal capsule or striatum, especially the dorsal sites, enhances the participants' cognitive control during a conflict task. We also show that closed-loop stimulation upon the detection of lapses in cognitive control produced larger behavioural changes than open-loop stimulation, and that task performance for single trials can be directly decoded from the activity of a small number of electrodes via neural features that are compatible with existing closed-loop brain implants. Closed-loop enhancement of cognitive control might remediate underlying cognitive deficits and aid the treatment of severe mental disorders.Entities:
Year: 2021 PMID： 34725508 PMCID： PMC9056584 DOI： 10.1038/s41551-021-00804-y
Source DB: PubMed Journal: Nat Biomed Eng ISSN： 2157-846X Impact factor: 29.234