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Literature DB >> 3472229

Natural UAG suppressor glutamine tRNA is elevated in mouse cells infected with Moloney murine leukemia virus.

Y Kuchino, H Beier, N Akita, S Nishimura.

Abstract

Two species of glutamine tRNA were isolated from mouse liver and their nucleotide sequences were determined. The minor glutamine tRNA(tRNA(UmUGGln)) that possesses UmUG (where Um stands for 2'-O-methyluridine) as the anticodon sequence was found to have suppressor activity for the UAG termination codon of tobacco mosaic virus RNA in a rabbit reticulocyte in vitro translation system. The amount of this suppressor glutamine tRNA in mouse liver was 1-2% of the amount of the major glutamine tRNA(tRNA(CUGGln)) that has the CUG anticodon sequence, but it was markedly increased in NIH 3T3 cells infected with Moloney murine leukemia virus and in Ehrlich ascites cells. These results support the hypothesis that tRNA(UmUGGln) actually functions in vivo as a suppressor tRNA that recognizes the UAG termination codon located at the gag-pol gene junction of Moloney murine leukemia virus and results in the synthesis of the virus-encoded protease.

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Year: 1987 PMID： 3472229 PMCID： PMC304719 DOI： 10.1073/pnas.84.9.2668

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

20 in total

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Authors: Y Yoshinaka; I Katoh; T D Copeland; S Oroszlan
Journal: Proc Natl Acad Sci U S A Date: 1985-03 Impact factor: 11.205

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Journal: EMBO J Date: 1986-02 Impact factor: 11.598

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Authors: H Beier; M Barciszewska; G Krupp; R Mitnacht; H J Gross
Journal: EMBO J Date: 1984-02 Impact factor: 11.598

41 in total

Review 1. Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs.

Authors: H Beier; M Grimm
Journal: Nucleic Acids Res Date: 2001-12-01 Impact factor: 16.971

2. Mutational analysis of the gag-pol junction of Moloney murine leukemia virus: requirements for expression of the gag-pol fusion protein.

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Journal: J Virol Date: 1992-11 Impact factor: 5.103

3. Compilation of tRNA sequences and sequences of tRNA genes.

Authors: M Sprinzl; N Dank; S Nock; A Schön
Journal: Nucleic Acids Res Date: 1991-04-25 Impact factor: 16.971

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6. Characterization of mouse mammary tumor virus gag-pro gene products and the ribosomal frameshift site by protein sequencing.

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Journal: Proc Natl Acad Sci U S A Date: 1987-10 Impact factor: 11.205

7. A comparative genomics analysis of codon reassignments reveals a link with mitochondrial proteome size and a mechanism of genetic code change via suppressor tRNAs.

Authors: Steven E Massey; James R Garey
Journal: J Mol Evol Date: 2007-03-27 Impact factor: 2.395

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Authors: N M Wills; R F Gesteland; J F Atkins
Journal: Proc Natl Acad Sci U S A Date: 1991-08-15 Impact factor: 11.205

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Journal: Plant Mol Biol Date: 1991-12 Impact factor: 4.076

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Authors: M Grimm; A Nass; C Schüll; H Beier
Journal: Plant Mol Biol Date: 1998-11 Impact factor: 4.076