Literature DB >> 34709429

Mechanobiology-based physical therapy and rehabilitation after orthobiologic interventions: a narrative review.

Janine McKay1, Mohammad Nasb2,3, Kholoud Hafsi4.   

Abstract

PURPOSE: This review aims to summarize the evidence for the role of mechanotherapies and rehabilitation in supporting the synergy between regeneration and repair after an orthobiologic intervention.
METHODS: A selective literature search was performed using Web of Science, OVID, and PubMed to review research articles that discuss the effects of combining mechanotherapy with various forms of regenerative medicine.
RESULTS: Various mechanotherapies can encourage the healing process for patients at different stages. Taping, bracing, cold water immersion, and extracorporeal shockwave therapy can be used throughout the duration of acute inflammatory response. The regulation of angiogenesis can be sustained with blood flow restriction and resistance training, whereas heat therapy and tissue loading during exercise are recommended in the remodeling phase.
CONCLUSION: Combining mechanotherapy with various forms of regenerative medicine has shown promise for improving treatment outcomes. However, further studies that reveal a greater volume of evidence are needed to support clinical decisions.
© 2021. The Author(s), under exclusive licence to The Author(s) under exclusive licence to SICOT aisbl.

Entities:  

Keywords:  Adipose tissue; Bio-orthopaedics; Mechanotherapy; Orthobiologics; Osteoarthritis; PRP; Regenerative; Rehabilitation; Stem cell therapy

Mesh:

Year:  2021        PMID: 34709429     DOI: 10.1007/s00264-021-05253-5

Source DB:  PubMed          Journal:  Int Orthop        ISSN: 0341-2695            Impact factor:   3.479


  66 in total

1.  Understanding Mechanobiology: Physical Therapists as a Force in Mechanotherapy and Musculoskeletal Regenerative Rehabilitation.

Authors:  William R Thompson; Alexander Scott; M Terry Loghmani; Samuel R Ward; Stuart J Warden
Journal:  Phys Ther       Date:  2015-12-04

2.  In vivo Differentiation Potential of Mesenchymal Stem Cells: Prenatal and Postnatal Model Systems.

Authors:  Courtney Quinn; Alan W Flake
Journal:  Transfus Med Hemother       Date:  2008-05-16       Impact factor: 3.747

Review 3.  Concepts in regenerative medicine: Past, present, and future in articular cartilage treatment.

Authors:  Adam W Anz; Asawari Bapat; William D Murrell
Journal:  J Clin Orthop Trauma       Date:  2016-06-15

Review 4.  Key developments that impacted the field of mechanobiology and mechanotransduction.

Authors:  Michelle Wall; David Butler; Alicia El Haj; Josephine C Bodle; Elizabeth G Loboa; Albert J Banes
Journal:  J Orthop Res       Date:  2017-09-05       Impact factor: 3.494

5.  Preliminary results of autologous adipose-derived stem cells in early knee osteoarthritis: identification of a subpopulation with greater response.

Authors:  Alfredo Schiavone Panni; Michele Vasso; Adriano Braile; Giuseppe Toro; Annalisa De Cicco; Davide Viggiano; Federica Lepore
Journal:  Int Orthop       Date:  2018-10-03       Impact factor: 3.075

Review 6.  Tensegrity, cellular biophysics, and the mechanics of living systems.

Authors:  Donald E Ingber; Ning Wang; Dimitrije Stamenovic
Journal:  Rep Prog Phys       Date:  2014-04

7.  Effects of medium supplements on proliferation, differentiation potential, and in vitro expansion of mesenchymal stem cells.

Authors:  Borzo Gharibi; Francis J Hughes
Journal:  Stem Cells Transl Med       Date:  2012-10-23       Impact factor: 6.940

Review 8.  Mechanotherapy: how physical therapists' prescription of exercise promotes tissue repair.

Authors:  K M Khan; A Scott
Journal:  Br J Sports Med       Date:  2009-02-24       Impact factor: 13.800

9.  Fibroblast-like cells differentiated from adipose-derived mesenchymal stem cells for vocal fold wound healing.

Authors:  Rong Hu; Wei Ling; Wen Xu; Demin Han
Journal:  PLoS One       Date:  2014-03-24       Impact factor: 3.240

10.  Efficacy and safety of culture-expanded, mesenchymal stem/stromal cells for the treatment of knee osteoarthritis: a systematic review protocol.

Authors:  Meredith Harrison-Brown; Corey Scholes; Kholoud Hafsi; Maimuna Marenah; Jinjie Li; Fadi Hassan; Nicola Maffulli; William D Murrell
Journal:  J Orthop Surg Res       Date:  2019-01-25       Impact factor: 2.359

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