Alfredo Schiavone Panni1, Michele Vasso1, Adriano Braile1, Giuseppe Toro2, Annalisa De Cicco1, Davide Viggiano3, Federica Lepore1. 1. Multidisciplinary Department of Medico-Surgical and Dentistry Specialties, University of the Campania "Luigi Vanvitelli", Via L. De Crecchio 4, 80138, Naples, Italy. 2. Multidisciplinary Department of Medico-Surgical and Dentistry Specialties, University of the Campania "Luigi Vanvitelli", Via L. De Crecchio 4, 80138, Naples, Italy. giusep.toro@gmail.com. 3. Department of Medical, Surgical, Neurological, Metabolic and Geriatrics Sciences, University of the Campania "Luigi Vanvitelli", Naples, Italy.
Abstract
PURPOSE: The purpose of this study was to report the clinical and functional results of a series of patients with early knee osteoarthritis (KOA) treated with the intra-articular injection of autologous adipose-derived stem cells (aASCs) plus arthroscopic debridement. The hypothesis was that protocol would significantly improve the clinical and functional outcomes in patients with early KOA. METHODS: Fifty-two patients with early KOA, who received arthroscopic debridement followed by percutaneous injection of aASCs, were enrolled into the study and retrospectively analyzed with an average follow-up of 15.3 (range, 6 to 24) months. Patients were assessed through the IKS knee and function scores and VAS pain scale. RESULTS: The mean IKS knee score improved from 37.4 (range, 14 to 79) points pre-operatively to 62.6 (range, 27 to 95) points at the latest follow-up (p < < 0.01). The mean IKS function score improved from 57.2 (range, 25 to 100) points pre-operatively to 83.0 (range, 35 to 100) points at the latest follow-up (p < < 0.01). The mean VAS score decreased from 8.5 (range, 3 to 10) pre-operatively to 5.1 (range, 0 to 8) at the latest follow-up (p < < 0.01). Additionally, patients with a pre-operative VAS score greater than 8 were found to show greater clinical and functional benefits compared with patients with VAS score lower than 8. CONCLUSIONS: The knee injection of aASCs associated to arthroscopic debridement increased significantly the clinical and functional scores in patients with early KOA at a mid-term follow-up, especially those with higher pre-operative VAS scores.
PURPOSE: The purpose of this study was to report the clinical and functional results of a series of patients with early knee osteoarthritis (KOA) treated with the intra-articular injection of autologous adipose-derived stem cells (aASCs) plus arthroscopic debridement. The hypothesis was that protocol would significantly improve the clinical and functional outcomes in patients with early KOA. METHODS: Fifty-two patients with early KOA, who received arthroscopic debridement followed by percutaneous injection of aASCs, were enrolled into the study and retrospectively analyzed with an average follow-up of 15.3 (range, 6 to 24) months. Patients were assessed through the IKS knee and function scores and VAS pain scale. RESULTS: The mean IKS knee score improved from 37.4 (range, 14 to 79) points pre-operatively to 62.6 (range, 27 to 95) points at the latest follow-up (p < < 0.01). The mean IKS function score improved from 57.2 (range, 25 to 100) points pre-operatively to 83.0 (range, 35 to 100) points at the latest follow-up (p < < 0.01). The mean VAS score decreased from 8.5 (range, 3 to 10) pre-operatively to 5.1 (range, 0 to 8) at the latest follow-up (p < < 0.01). Additionally, patients with a pre-operative VAS score greater than 8 were found to show greater clinical and functional benefits compared with patients with VAS score lower than 8. CONCLUSIONS: The knee injection of aASCs associated to arthroscopic debridement increased significantly the clinical and functional scores in patients with early KOA at a mid-term follow-up, especially those with higher pre-operative VAS scores.
Authors: Richard Kijowski; Donna Blankenbaker; Paul Stanton; Jason Fine; Arthur De Smet Journal: AJR Am J Roentgenol Date: 2006-09 Impact factor: 3.959
Authors: Marie L Misso; Veronica J Pitt; Kay M Jones; Hayley N Barnes; Leon Piterman; Sally E Green Journal: Med J Aust Date: 2008-10-06 Impact factor: 7.738
Authors: Jan Philipp Krüger; Undine Freymannx; Samuel Vetterlein; Katja Neumann; Michaela Endres; Christian Kaps Journal: Transfus Med Hemother Date: 2013-10-27 Impact factor: 3.747
Authors: Tomislav Ćuti; Maja Antunović; Inga Marijanović; Alan Ivković; Andreja Vukasović; Igor Matić; Marko Pećina; Damir Hudetz Journal: Int Orthop Date: 2017-03-15 Impact factor: 3.075
Authors: Yves-Marie Pers; Lars Rackwitz; Rosanna Ferreira; Oliver Pullig; Christophe Delfour; Frank Barry; Luc Sensebe; Louis Casteilla; Sandrine Fleury; Philippe Bourin; Danièle Noël; François Canovas; Catherine Cyteval; Gina Lisignoli; Joachim Schrauth; Daniel Haddad; Sophie Domergue; Ulrich Noeth; Christian Jorgensen Journal: Stem Cells Transl Med Date: 2016-05-23 Impact factor: 6.940
Authors: Ahmed Samir Barakat; Nour Muhamad Ibrahim; Osama Elghobashy; Ahmed Maher Sultan; Khaled F M Abdel-Kader Journal: Int Orthop Date: 2019-06-22 Impact factor: 3.075
Authors: Perry Liu; Binay Gurung; Irrum Afzal; Matteo Santin; David H Sochart; Richard E Field; Deiary F Kader; Vipin Asopa Journal: J Exp Orthop Date: 2022-10-09