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Literature DB >> 3470764

Nesting: hierarchies of allosteric interactions.

C H Robert, H Decker, B Richey, S J Gill, J Wyman.

Abstract

A generalization of the allosteric model is presented that incorporates a hierarchy of conformational equilibria. Such a formulation draws upon structural organization already seen in many large macromolecular systems. The functional binding properties of the macromolecule reflect conformational equilibria at each structural level. Appropriate "nested" models are used to interpret structural features and functional aspects of two hemocyanin systems with a large number (12 and 24) of binding sites.

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Year: 1987 PMID： 3470764 PMCID： PMC304547 DOI： 10.1073/pnas.84.7.1891

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

16 in total

1. ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.

Authors: J MONOD; J WYMAN; J P CHANGEUX
Journal: J Mol Biol Date: 1965-05 Impact factor: 5.469

2. Analysis of the effect of three different allosteric ligands on oxygen binding by hemocyanin of the shrimp, Penaeus setiferus.

Authors: M Brouwer; C Bonaventura; J Bonaventura
Journal: Biochemistry Date: 1978-05-30 Impact factor: 3.162

7. Crystallization and preliminary analysis of crystals of the 24-meric hemocyanin of the emperor scorpion (Pandinus imperator).

Authors: Elmar Jaenicke; Bruno Pairet; Hermann Hartmann; Heinz Decker
Journal: PLoS One Date: 2012-03-05 Impact factor: 3.240

7 in total

Nesting: hierarchies of allosteric interactions.

1. ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.

2. Analysis of the effect of three different allosteric ligands on oxygen binding by hemocyanin of the shrimp, Penaeus setiferus.

3. Oxygen binding by callianassa californiensis hemocyanin.

4. Thin-layer fluorescence cell for ligand binding studies.

5. Allosteric properties and the association equilibria of hemocyanin from Callianassa californiensis.

6. Membrane-covered thin-layer optical cell for gas-reaction studies of hemoglobin.

7. Hemocyanins in spiders, XV. The role of the individual subunits in the assembly of Eurypelma hemocyanin.

8. Comparison of experimental binding data and theoretical models in proteins containing subunits.

9. Oxygen-binding characteristics of Potamilla chlorocruorin.

10. Binding of oxygen and carbon monoxide to arthropod hemocyanin: an allosteric analysis.

Review 1. [Hierarchies in the structure and function of oxygen-binding proteins].

2. Chromatin fiber functional organization: some plausible models.

3. A hierarchical approach to cooperativity in macromolecular and self-assembling binding systems.

4. Two-photon excitation microscopy of tryptophan-containing proteins.

5. Inversion of the Bohr effect upon oxygen binding to 24-meric tarantula hemocyanin.

6. Allosteric conformational ensembles have unlimited capacity for integrating information.

7. Crystallization and preliminary analysis of crystals of the 24-meric hemocyanin of the emperor scorpion (Pandinus imperator).