Mitali Ray1, Lacey W Heinsberg2,3,4, Yvette P Conley1,2, James M Roberts4,5,6,7,8, Arun Jeyabalan4,5,6,8, Carl A Hubel5,6,9, Daniel E Weeks2,10, Mandy J Schmella1. 1. Department of Health Promotion and Development, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 2. Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 3. Division of Internal Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 4. Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 5. Department of Obstetrics, Gynecology, & Reproductive Sciences, University of Pittsburgh, Pittsburgh, USA. 6. Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA. 7. Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 8. Global Pregnancy Collaboration, Pittsburgh, Pennsylvania, USA. 9. Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 10. Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Abstract
Objective: Examine white blood cell (WBC) proportions across preeclamptic (n = 28 cases) and normotensive (n = 28 controls) pregnancy in individuals with overweight/obesity. Methods: WBC proportions were inferred from genome-wide DNA methylation data and compared by case/control status and self-identified race. Results: In Trimester 1, ean B cell proportions were suggestively lower in cases in the overall sample and significantly lower in White participants but not in Black participants. More significant WBC proportion changes were observed across normotensive than preeclamptic pregnancy.Conclusions: These findings in a small sample demonstrate need for additional studies investigating the relationship between self-identified race and WBCs in pregnancy.
Objective: Examine white blood cell (WBC) proportions across preeclamptic (n = 28 cases) and normotensive (n = 28 controls) pregnancy in individuals with overweight/obesity. Methods: WBC proportions were inferred from genome-wide DNA methylation data and compared by case/control status and self-identified race. Results: In Trimester 1, ean B cell proportions were suggestively lower in cases in the overall sample and significantly lower in White participants but not in Black participants. More significant WBC proportion changes were observed across normotensive than preeclamptic pregnancy.Conclusions: These findings in a small sample demonstrate need for additional studies investigating the relationship between self-identified race and WBCs in pregnancy.
Entities:
Keywords:
DNA methylation; Preeclampsia; WBC count; hypertension in pregnancy; white blood cell
Authors: Lacey W Heinsberg; Mitali Ray; Yvette P Conley; James M Roberts; Arun Jeyabalan; Carl A Hubel; Daniel E Weeks; Mandy J Schmella Journal: Reprod Sci Date: 2021-04-20 Impact factor: 3.060