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Literature DB >> 3469155

Study of the cerebrospinal fluid penetrability of ofloxacin.

Abstract

In patients with different neurological diseases with blood-brain barrier dysfunction subjected to diagnostic CSF-tap, simultaneous determinations of ofloxacin concentrations in serum and in CSF were carried out. The results show that ofloxacin penetrates well into the CSF achieving adequate bactericidal concentrations against most of the common causative pathogens of meningitis.

Entities: Chemical Disease Gene Species

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Year: 1986 PMID： 3469155 DOI： 10.1007/BF01661285

Source DB: PubMed Journal: Infection ISSN： 0300-8126 Impact factor: 3.553

3 in total

1. The discrimination between different blood-CSF barrier dysfunctions and inflammatory reactions of the CNS by a recent evaluation graph for the protein profile of cerebrospinal fluid.

Authors: H Reiber
Journal: J Neurol Date: 1980 Impact factor: 4.849

2. In-vitro activity of enoxacin, ofloxacin, norfloxacin and nalidixic acid.

Authors: A Bauernfeind; U Ullmann
Journal: J Antimicrob Chemother Date: 1984-09 Impact factor: 5.790

3. Comparison of the antibacterial in vitro and in vivo activity of ofloxacin (HOE 280 DL 8280) and nalidixic acid analogues.

Authors: G Seibert; M Limbert; N Klesel
Journal: Eur J Clin Microbiol Date: 1983-12 Impact factor: 3.267

3 in total

6 in total

Review 1. Ofloxacin clinical pharmacokinetics.

Authors: K C Lamp; E M Bailey; M J Rybak
Journal: Clin Pharmacokinet Date: 1992-01 Impact factor: 6.447

Study of the cerebrospinal fluid penetrability of ofloxacin.

1. The discrimination between different blood-CSF barrier dysfunctions and inflammatory reactions of the CNS by a recent evaluation graph for the protein profile of cerebrospinal fluid.

2. In-vitro activity of enoxacin, ofloxacin, norfloxacin and nalidixic acid.

3. Comparison of the antibacterial in vitro and in vivo activity of ofloxacin (HOE 280 DL 8280) and nalidixic acid analogues.

Review 1. Ofloxacin clinical pharmacokinetics.

Review 2. Clinical pharmacokinetics of the newer antibacterial 4-quinolones.

Review 3. Potential role of fluoroquinolones in the treatment of bacterial meningitis.

4. Penetration of ciprofloxacin into human cerebrospinal fluid in patients with inflamed and non-inflamed meninges.

5. Diffusion of ofloxacin into cerebrospinal fluid of patients with purulent meningitis or ventriculitis.

Review 6. Pharmacokinetic disposition of quinolones in human body fluids and tissues.