Lina Nurhussien1, Choong-Min Kang2, Petros Koutrakis2, Brent A Coull2, Mary B Rice1. 1. Division of Pulmonary, Sleep and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; and. 2. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Abstract
Rationale: Few studies have assessed personal exposure to pollutants and lung function among adults with chronic obstructive pulmonary disease (COPD). Blood eosinophil level may be a biomarker of airway inflammation and pollution susceptibility. Objectives: To evaluate if daily pollutant exposures are associated with lung function and if associations are modified by eosinophil level in COPD. Methods: We recruited 30 former smokers with moderate to severe COPD living in the Boston area and followed them for up to 4 nonconsecutive months in different seasons. Participants measured morning lung function and carried a portable air quality monitor daily. Previous-day exposure to pollutants (particulate matter ⩽2.5 μm in aerodynamic diameter, nitrogen dioxide [NO2], and ozone) were measured by portable and community monitors. We constructed multilevel linear mixed-effects models with random intercepts for person and observation month, adjusted for temperature, humidity, age, sex, race, height, weight, income, and season, to assess associations of previous-day pollutant exposure with lung function and effect modification by eosinophil count (<150/μl vs. ⩾150/μl). Results: A total of 3,314 observations with exposure and lung function data were collected. Each interquartile range (5.1 parts per billion [ppb])-higher previous-day personal exposure to NO2 was associated with an 11.3 ml (95% confidence interval [CI], -18.7 to -4.0) lower forced expiratory volume in 1 second (FEV1) and an 18.0 ml (95% CI, -32.0 to -4.2) lower forced vital capacity. Personal and community-level exposure to particulate matter ⩽2.5 μm in aerodynamic diameter and community-level NO2 were negatively associated with FEV1 among the 55.2% of participants with the higher eosinophil level (Pinteraction < 0.05). Conclusions: Our study highlights the need to address air pollution exposure among patients with COPD. Future research is needed to verify if eosinophil level is a biomarker for susceptibility to air pollution in COPD.
Rationale: Few studies have assessed personal exposure to pollutants and lung function among adults with chronic obstructive pulmonary disease (COPD). Blood eosinophil level may be a biomarker of airway inflammation and pollution susceptibility. Objectives: To evaluate if daily pollutant exposures are associated with lung function and if associations are modified by eosinophil level in COPD. Methods: We recruited 30 former smokers with moderate to severe COPD living in the Boston area and followed them for up to 4 nonconsecutive months in different seasons. Participants measured morning lung function and carried a portable air quality monitor daily. Previous-day exposure to pollutants (particulate matter ⩽2.5 μm in aerodynamic diameter, nitrogen dioxide [NO2], and ozone) were measured by portable and community monitors. We constructed multilevel linear mixed-effects models with random intercepts for person and observation month, adjusted for temperature, humidity, age, sex, race, height, weight, income, and season, to assess associations of previous-day pollutant exposure with lung function and effect modification by eosinophil count (<150/μl vs. ⩾150/μl). Results: A total of 3,314 observations with exposure and lung function data were collected. Each interquartile range (5.1 parts per billion [ppb])-higher previous-day personal exposure to NO2 was associated with an 11.3 ml (95% confidence interval [CI], -18.7 to -4.0) lower forced expiratory volume in 1 second (FEV1) and an 18.0 ml (95% CI, -32.0 to -4.2) lower forced vital capacity. Personal and community-level exposure to particulate matter ⩽2.5 μm in aerodynamic diameter and community-level NO2 were negatively associated with FEV1 among the 55.2% of participants with the higher eosinophil level (Pinteraction < 0.05). Conclusions: Our study highlights the need to address air pollution exposure among patients with COPD. Future research is needed to verify if eosinophil level is a biomarker for susceptibility to air pollution in COPD.
Authors: Steven Pascoe; Neil Barnes; Guy Brusselle; Chris Compton; Gerard J Criner; Mark T Dransfield; David M G Halpin; MeiLan K Han; Benjamin Hartley; Peter Lange; Sally Lettis; David A Lipson; David A Lomas; Fernando J Martinez; Alberto Papi; Nicolas Roche; Ralf J P van der Valk; Robert Wise; Dave Singh Journal: Lancet Respir Med Date: 2019-07-04 Impact factor: 30.700
Authors: Philip E Silkoff; Lening Zhang; Steven Dutton; Esther L Langmack; Sverre Vedal; James Murphy; Barry Make Journal: J Allergy Clin Immunol Date: 2005-02 Impact factor: 10.793
Authors: Francesca Dominici; Roger D Peng; Michelle L Bell; Luu Pham; Aidan McDermott; Scott L Zeger; Jonathan M Samet Journal: JAMA Date: 2006-03-08 Impact factor: 56.272
Authors: Janet L Peacock; H Ross Anderson; Stephen A Bremner; Louise Marston; Terence A Seemungal; David P Strachan; Jadwiga A Wedzicha Journal: Thorax Date: 2011-04-01 Impact factor: 9.139
Authors: Lia Chatzidiakou; Anika Krause; Yiqun Han; Wu Chen; Li Yan; Olalekan A M Popoola; Mike Kellaway; Yangfeng Wu; Jing Liu; Min Hu; Ben Barratt; Frank J Kelly; Tong Zhu; Roderic L Jones Journal: J Expo Sci Environ Epidemiol Date: 2020-08-12 Impact factor: 5.563
Authors: Charlotte Scheerens; Lina Nurhussien; Amro Aglan; Andrew J Synn; Brent A Coull; Petros Koutrakis; Mary B Rice Journal: ERJ Open Res Date: 2022-03-14