Literature DB >> 34677662

Role of bacterial colonisation of vancomycin-gentamicin spacers in two-stage arthroplasty revision surgery: the usefulness of spacer sonication.

Sandra Huguet1,2, Martí Bernaus3,4, Lucía Gómez4,5, Eva Cuchí4,6, Alex Soriano7, Lluís Font-Vizcarra3,4.   

Abstract

PURPOSE: In two-stage replacements for septic loosening, some studies have suggested an association between bacterial colonisation of spacers and a higher number of complications after implantation of the definitive prosthesis. Our study aimed to determine the reoperation rate of patients undergoing two-stage revision surgery according to the culture results of spacer sonication.
METHODS: A retrospective observational study was conducted in which hip or knee spacers implanted at our institution with a diagnosis of periprosthetic joint infection from 2010 to 2018 were analysed. Patients were grouped into three categories: A. Patients with positive spacer sonication fluid culture, with or without positive cultures of the rest of the samples. B. Patients with negative spacer sonication culture and negative cultures of the rest of intraoperative samples. C. Patients with negative spacer sonication culture but positive cultures of the rest of intraoperative samples.
RESULTS: A total of 45 spacers were analysed: 10 were included in group A, 24 in group B and 11 in group C. The reoperation rate during the first year after the 2-stage revision surgery was 20%, 29.2% and 54.5% for each group, respectively, due to an infection in 10%, 20.8% and 45.5%. Spacers were colonised in all cases by low virulent micro-organisms.
CONCLUSION: In our study, bacterial colonisation of the spacer is not associated with a higher rate of reoperation. The group of patients with positive intraoperative cultures during the second-stage had the highest reoperation rate.
© 2021. The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature.

Entities:  

Keywords:  Periprosthetic joint infection; Revision surgery; Sonication; Spacer; Two-stage surgery

Year:  2021        PMID: 34677662     DOI: 10.1007/s00590-021-03151-5

Source DB:  PubMed          Journal:  Eur J Orthop Surg Traumatol        ISSN: 1633-8065


  18 in total

1.  Sonication of antibiotic spacers predicts failure during two-stage revision for prosthetic knee and hip infections.

Authors:  Charles L Nelson; Robert B Jones; Nathaniel C Wingert; Michael Foltzer; Thomas R Bowen
Journal:  Clin Orthop Relat Res       Date:  2014-07       Impact factor: 4.176

Review 2.  Systematic review comparing static and articulating spacers used for revision of infected total knee arthroplasty.

Authors:  Robert Pivec; Qais Naziri; Kimona Issa; Samik Banerjee; Michael A Mont
Journal:  J Arthroplasty       Date:  2013-09-05       Impact factor: 4.757

3.  Two-stage revision arthroplasty of the hip for infection using an interim articulated Prostalac hip spacer: a 10- to 15-year follow-up study.

Authors:  G S Biring; T Kostamo; D S Garbuz; B A Masri; C P Duncan
Journal:  J Bone Joint Surg Br       Date:  2009-11

4.  Current Epidemiology of Revision Total Knee Arthroplasty in the United States.

Authors:  Ronald E Delanois; Jaydev B Mistry; Chukwuweike U Gwam; Nequesha S Mohamed; Ujval S Choksi; Michael A Mont
Journal:  J Arthroplasty       Date:  2017-04-06       Impact factor: 4.757

5.  Two-stage exchange knee arthroplasty: does resistance of the infecting organism influence the outcome?

Authors:  Mark F Kurd; Elie Ghanem; Jill Steinbrecher; Javad Parvizi
Journal:  Clin Orthop Relat Res       Date:  2010-08       Impact factor: 4.176

6.  Comparative Epidemiology of Revision Arthroplasty: Failed THA Poses Greater Clinical and Economic Burdens Than Failed TKA.

Authors:  Kevin J Bozic; Atul F Kamath; Kevin Ong; Edmund Lau; Steve Kurtz; Vanessa Chan; Thomas P Vail; Harry Rubash; Daniel J Berry
Journal:  Clin Orthop Relat Res       Date:  2014-12-03       Impact factor: 4.176

7.  Diagnosis of spacer-associated infection using quantitative cultures from sonicated antibiotics-loaded spacers: implications for the clinical outcome.

Authors:  J Esteban; I Gadea; C Pérez-Jorge; E Sandoval; J García-Cañete; R Fernandez-Roblas; A Blanco; L Prieto-Borja; J Cordero-Ampuero
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2015-11-26       Impact factor: 3.267

8.  Analysis of Total Knee Arthroplasty revision causes.

Authors:  Anne Postler; Cornelia Lützner; Franziska Beyer; Eric Tille; Jörg Lützner
Journal:  BMC Musculoskelet Disord       Date:  2018-02-14       Impact factor: 2.362

9.  Periprosthetic infection is the major indication for TKA revision - experiences from a university referral arthroplasty center.

Authors:  S P Boelch; A Jakuscheit; S Doerries; L Fraissler; M Hoberg; J Arnholdt; M Rudert
Journal:  BMC Musculoskelet Disord       Date:  2018-11-10       Impact factor: 2.362

10.  Sonication of antibiotic-loaded cement spacers in a two-stage revision protocol for infected joint arthroplasty.

Authors:  Massimo Mariconda; Tiziana Ascione; Giovanni Balato; Renato Rotondo; Francesco Smeraglia; Giovan Giuseppe Costa; Marco Conte
Journal:  BMC Musculoskelet Disord       Date:  2013-06-24       Impact factor: 2.362

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